Leukocyte trafficking into lymphoid tissues or sites of infection or injury is regulated by the coordinated expression of adhesion and signaling molecules [1, 2]. Binding of selecfins to glycoconjugate ligands mediates tethering and rolling on vascular surfaces. Binding of leukocyte integrins to Ig-like proteins slows rolling, promotes firm adhesion, and directs migration. Cytokines, thrombin, histamine, and other mediators inifiate leukocyte recruitment by stimulafing endothelial cells to express adhesion molecules and chemokines. Rolling leukocytes receive signals from engagement of selecfin ligands and chemokines that cause integrin-dependent deceleration, arrest, and migration. Combinatorial diversity of adhesion and signaling molecules controls the number and type of leukocytes recruited to a particular tissue, as well as the duration of the response. Dysregulated expression of these molecules contributes to tissue injury in inflammatory diseases.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL085607-08
Application #
8469888
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
8
Fiscal Year
2013
Total Cost
$580,147
Indirect Cost
$229,191
Name
Oklahoma Medical Research Foundation
Department
Type
DUNS #
077333797
City
Oklahoma City
State
OK
Country
United States
Zip Code
73104
Herzog, Brett H; Fu, Jianxin; Xia, Lijun (2014) Mucin-type O-glycosylation is critical for vascular integrity. Glycobiology 24:1237-41
Sreeramkumar, Vinatha; Adrover, José M; Ballesteros, Ivan et al. (2014) Neutrophils scan for activated platelets to initiate inflammation. Science 346:1234-8
Stowell, Sean R; Arthur, Connie M; McBride, Ryan et al. (2014) Microbial glycan microarrays define key features of host-microbial interactions. Nat Chem Biol 10:470-6
Liu, Xiaolei; Pasula, Satish; Song, Hoogeun et al. (2014) Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function. Sci Signal 7:ra97
Wan, Xiang; Sato, Hidetaka; Miyaji, Hiromasa et al. (2013) Fucosyltransferase VII improves the function of selectin ligands on cord blood hematopoietic stem cells. Glycobiology 23:1184-91
Herzog, Brett H; Fu, Jianxin; Wilson, Stephen J et al. (2013) Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature 502:105-9
Shao, Bojing; Yago, Tadayuki; Coghill, Phillip A et al. (2012) Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin *L*2. J Biol Chem 287:19585-98
Miner, Jonathan J; Shao, Bojing; Wang, Ying et al. (2011) Cytoplasmic domain of P-selectin glycoprotein ligand-1 facilitates dimerization and export from the endoplasmic reticulum. J Biol Chem 286:9577-86
Shao, Bojing; Wahrenbrock, Mark G; Yao, Longbiao et al. (2011) Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome. Blood 118:4015-23
Cerliani, Juan P; Stowell, Sean R; Mascanfroni, Ivan D et al. (2011) Expanding the universe of cytokines and pattern recognition receptors: galectins and glycans in innate immunity. J Clin Immunol 31:10-21

Showing the most recent 10 out of 37 publications