Core C The purpose of the Biostatistics and Data Management Core (BDMC) for this program project grant is to provide a comprehensive, multi-disciplinary resource for design of clinical and basic science studies, development of appropriate and innovative statistical methodology, statistical analysis, and summarization of the results. The Biostatistics and Data Management Core has the following overall goals: To provide statistical consulting and collaboration on the design, conduct, analysis and interpretation for individual projects and across projects and to provide, manage and maintain a high-quality relational research database that supports the research projects and cores while preserving the confidentiality of all subject data.
The specific aims are: (1) Coordinate and manage statistical activities for all research studies to ensure that investigators have ready access to statistical consultation and support. (2) Provide statistical expertise in the design of experiments and studies, including research proposal development, sample size determination, and plans for interim reviews and final analysis. (3) Assist with the writing of statistical components of manuscripts. (4) Review the integrity and statistical soundness of all studies involving human subjects. (5) Provide statistical analysis for all projects using appropriate statistical and computing methodologies, assist in the interpretation and presentation of results. (6) Maintain a computing facility with up-to-date software for statistical analysis to support all research investigators. (7) Provide computer-based tools that facilitate the storage and retrieval of the data generated in the proposed research, thereby creating and maintaining a centralized relational database that provides access to common resources and information. (8) Ensure the accuracy of the data maintained in the database by software based data consistency and quality control systems. (9) Organize and maintain the database to maximize accuracy and accessibility, while maintaining strict confidentiality. (10) Provide detailed descriptions of the available populations and resources for current and future investigators. (11) Collaborate with clinical investigators to design Case Report Forms and provide high-quality data entry services. The BDMC will interact and directly support all Projects in the program project grant. Core C will allow investigators involved in each of the 4 projects to have a formalized, ongoing and collaborative interaction and arrangement with an outstanding biostatistics department in one of the leading public health schools in the United States.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL086773-04
Application #
8342009
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2008-09-15
Project End
2013-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
4
Fiscal Year
2011
Total Cost
$203,612
Indirect Cost
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
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Hammadah, Muhammad; Al Mheid, Ibhar; Wilmot, Kobina et al. (2017) The Mental Stress Ischemia Prognosis Study: Objectives, Study Design, and Prevalence of Inducible Ischemia. Psychosom Med 79:311-317
Qi, Zhen; Roback, John D; Voit, Eberhard O (2017) Effects of Storage Time on Glycolysis in Donated Human Blood Units. Metabolites 7:
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Hammadah, Muhammad; Al Mheid, Ibhar; Wilmot, Kobina et al. (2017) Telomere Shortening, Regenerative Capacity, and Cardiovascular Outcomes. Circ Res 120:1130-1138
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Pakvasa, Mitali A; Winkler, Anne M; Hamrick, Shannon E et al. (2017) Observational study of haemostatic dysfunction and bleeding in neonates with hypoxic-ischaemic encephalopathy. BMJ Open 7:e013787
Hayek, Salim S; Klyachkin, Yuri; Asfour, Ahmed et al. (2017) Bioactive Lipids and Circulating Progenitor Cells in Patients with Cardiovascular Disease. Stem Cells Transl Med 6:731-735
Patel, Ravi M; Knezevic, Andrea; Shenvi, Neeta et al. (2016) Association of Red Blood Cell Transfusion, Anemia, and Necrotizing Enterocolitis in Very Low-Birth-Weight Infants. JAMA 315:889-97
Auletta, J J; Devine, S M; Waller, E K (2016) Plasmacytoid dendritic cells in allogeneic hematopoietic cell transplantation: benefit or burden? Bone Marrow Transplant 51:333-43

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