The administrative core will provide the organizational backbone for the overall proposal, coordinating theinternal interactions between Projects and Cores as well as the external communication with NHLBI throughthe following specific aims:Specific Task 1: To facilitate communication between Projects 1-4 and Cores A and B and assist all projectsin manuscript preparation. >Specific Task 2: To provide mechanisms for communication between UW, the Institute and projectreviewers.Specific Task 3: To provide regulatory support to all projects and cores through interactions with the UW IRBand the FDA.The administrative core will interact with all projects and cores in this proposal through organization,notification and meeting minute distribution of monthly internal project review meetings. The administrativecore will oversee the rate of subject accrual to assure that each project is able to meet its required samplesize. The core will be responsible for preparation and submission of annual progress reports to the Instituteand will organize external reviews as needed and the core will work with the FDA to obtain an InvestigationalNew Drug application for the proposed use of anti-IL-5 antibody. The administrative core will assist allprojects in collaborative manuscript preparation and preparation of slides for data presentations.
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