The Mouse and Tissue Core (Core B) is designed to enhance the scientific objectives and cost-effectivenessof the Program Project in the following ways: 1) by serving as a central facility for the breeding andmaintenance of mouse models of diabetes and atherosclerosis utilized by program project investigators, 2)by participating in the planning and implementation of longitudinal studies of these murine models, 3) byserving as a central facility for the collection and processing (freezing and/or fixation and paraffinembedding) of tissues and cells from these murine models, 4) by providing investigators with expertise inpathology-based analytical techniques such as histological staining, immunohistochemistry,immunofluorescence microscopy and in situ hybridization, most of which will be performed in this Core unit,and 5) by quantifying and characterizing atherosclerotic lesions and providing morphological characterizationof other tissues taken from murine models used by program project investigators. Centralizing andstandardizing planning, breeding and maintenance of mice for animal experiments, as well as tissuecollection and methods of analyses in a single, integrated Core will increase the likelihood of obtainingreliable results and not compel individual Projects to perform duplicative animal experiments or to developtechnical expertise in these areas. Further, carrying out these studies in a single, integrated Core will allowthe results to be made available to each project in a way that facilitates Project interactions.
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