The Imaging Core, located in the Pulmonary Imaging Center will act as a central facility to handle and process the large number of MRI's and MR data analysis generated by Projects 01, 02 and 03. The objectives of the Imaging Core are to: 1) transfer data from the MRI to the Pulmonary Imaging Center;2) ensure proper data analysis of the MR images, 3) perform quantitative analysis of upper airway soft tissue and craniofacial structures on spin echo MRI, quantify tongue fat with Dixon imaging and MR spectroscopy, quantify visceral abdominal fat, quantify LV size and aortic stiffness;4) ensure quality control of the MR images;and 5) establish new computer analysis three-dimensional image analysis programs. The MR images will be electronically transferred to the Pulmonary Imaging Center via a Picture Archiving and Communication System (PACS). The image analysis will be performed in the Pulmonary Imaging Center where there are 4 Sun workstations running a completely novel software package developed for the analysis of three-dimensional images (Volumetric Image Display and Analysis, VIDA). We will also utilize AMIRA software - Advanced Visualization and Volume Modeling for volumetric display of the data. TheMR data analysis is complicated and cannot be performed without significant training. Dr. Schwab has been the director of the Pulmonary Imaging Center since 1991 and has an established track record for analyzing such data. The large number of MRI's justifies the establishment of a core devoted to the performing the complicated analysis proposed in Projects 01, 02 and 03. A centralized facility will ensure quality control of the data and cost effectiveness. We will perform MRI's at the University of Pennsylvania and in Iceland. We have already had a successful collaboration with the Iceland MR team in a large ongoing NIH funded Icelandic study ("A Family Linkage Study of Obstructive Sleep Apnea" (HL072067)) in which 391 MRI's of the upper airway and of visceral abdominal fat have been performed. Over 300 of these MRI's have already been analyzed. The Magnetic Resonance Imaging Core will be under the leadership of Dr. Richard Schwab with support staff consisting of senior research radiologists (visceral abdominal fat (Dr. Torigian), MR spectroscopy (Dr. Poptani), image processing, reconstruction and threshold analysis (Dr. Udupa) and two research technicians to perform and validate the image analysis. Development of a central core facility with expertise in upper airway and volumetric abdominal visceral fat imaging will facilitate the proposed research by standardizing the imaging analysis paradigms, allow the development of new image analysis approaches and ensure quality assurance/reproducibility across all three research projects.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
Project #
Application #
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pennsylvania
United States
Zip Code
Bjornsdottir, Erla; Keenan, Brendan T; Eysteinsdottir, Bjorg et al. (2015) Quality of life among untreated sleep apnea patients compared with the general population and changes after treatment with positive airway pressure. J Sleep Res 24:328-38
Arnardottir, Erna S; Lim, Diane C; Keenan, Brendan T et al. (2015) Effects of obesity on the association between long-term sleep apnea treatment and changes in interleukin-6 levels: the Icelandic Sleep Apnea Cohort. J Sleep Res 24:148-59
Pak, V M; Keenan, B T; Jackson, N et al. (2015) Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity. Int J Obes (Lond) 39:472-9
Iftikhar, Imran H; Valentine, Christopher W; Bittencourt, Lia R A et al. (2014) Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a meta-analysis. J Hypertens 32:2341-50; discussion 2350
Kim, Andrew M; Keenan, Brendan T; Jackson, Nicholas et al. (2014) Tongue fat and its relationship to obstructive sleep apnea. Sleep 37:1639-48
Kim, Jinyoung; Pack, Allan; Maislin, Greg et al. (2014) Prospective observation on the association of snoring with subclinical changes in carotid atherosclerosis over four years. Sleep Med 15:769-75
Brown, Marishka K; Chan, May T; Zimmerman, John E et al. (2014) Aging induced endoplasmic reticulum stress alters sleep and sleep homeostasis. Neurobiol Aging 35:1431-41
Sutherland, Kate; Schwab, Richard J; Maislin, Greg et al. (2014) Facial phenotyping by quantitative photography reflects craniofacial morphology measured on magnetic resonance imaging in Icelandic sleep apnea patients. Sleep 37:959-68
Chirinos, Julio A; Gurubhagavatula, Indira; Teff, Karen et al. (2014) CPAP, weight loss, or both for obstructive sleep apnea. N Engl J Med 370:2265-75
Schwab, Richard J; Kim, C; Siegel, Lawrence et al. (2014) Examining the mechanism of action of a new device using oral pressure therapy for the treatment of obstructive sleep apnea. Sleep 37:1237-47

Showing the most recent 10 out of 23 publications