The Molecular Assessment Core will be primarily located in the Translational Research Laboratory (TRL), the same building which houses the Center for Sleep and Circadian Neurobiology. The functioning of the Molecular Assessment Core will take advantage of existing facilities and the sophisticated equipment already available within the Translational Research Laboratory. The Molecular Assessment Core will act as a central facility to collect, process and analyze the large number of incoming blood and urine samples generated by the Projects 02 and 03. Importantly, the Molecular Assessment Core will ensure quality control of all samples collected by the proposed projects. The objectives of the Molecular Assessment Core are to: 1) standardize blood and urine collection between sites, 2) ensure proper handling and storage of samples, 3) code, record and monitor incoming samples, 4) ensure quality control of assays and 5) provide a centralized facility for assays. The Molecular Assessment Core will be under the leadership of Dr. Allan I. Pack, with support staff consisting of two experienced research specialists.

Public Health Relevance

Understanding the basis of individual differences in consequences of sleep apnea requires assessment of effects at a molecular level. This Core provides this both for the project in humans (Project 02) and in mice (Project 03).

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL094307-08
Application #
9502852
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Program Officer
Laposky, Aaron D
Project Start
Project End
Budget Start
2018-05-01
Budget End
2019-04-30
Support Year
8
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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