Core B: Outcomes Core (Core B: Minami) The Outcomes Core has 4 objectives 1) To provide surgical models of myocardial infarction to serve as a basis for studying the effects of stem-cell therapy in myocardial infarct repair. 2) To provide in-vivo physiology endpoint measurements using echocardiography, MRI, and microspheres to determine functional improvement post-engraftment 3) To provide basic tissue preparation and sectioning to allow each project to study endpoints at the fissue level. 4) To develop a canine model of myocardial infarction and grafting techniques to allow us to study the effects of embryonic-stem cell derived cardiomyocytes and mesenchymal stem cells in large animal models so that we can be one step closer to bringing this therapy to the clinical setting.
The long term goal of this Core is to assist investigators in this project to study how stem cells and embryonic stem cell-derived cardiomyocytes improve cardiac function so that eventually, these cells can be potentially used as treatment for patients with ischemic cardiomyopathy.
|Lundy, Scott D; Gantz, Jay A; Pagan, Chelsea M et al. (2014) Pluripotent stem cell derived cardiomyocytes for cardiac repair. Curr Treat Options Cardiovasc Med 16:319|
|Jiao, Alex; Trosper, Nicole E; Yang, Hee Seok et al. (2014) Thermoresponsive nanofabricated substratum for the engineering of three-dimensional tissues with layer-by-layer architectural control. ACS Nano 8:4430-9|
|Chong, James J H; Murry, Charles E (2014) Cardiac regeneration using pluripotent stem cells--progression to large animal models. Stem Cell Res 13:654-65|
|Coulombe, Kareen L K; Bajpai, Vivek K; Andreadis, Stelios T et al. (2014) Heart regeneration with engineered myocardial tissue. Annu Rev Biomed Eng 16:1-28|
|Lundy, Scott D; Murphy, Sean A; Dupras, Sarah K et al. (2014) Cell-based delivery of dATP via gap junctions enhances cardiac contractility. J Mol Cell Cardiol 72:350-9|
|Hartman, Matthew E; Liu, Yonggang; Zhu, Wei-Zhong et al. (2014) Myocardial deletion of transcription factor CHF1/Hey2 results in altered myocyte action potential and mild conduction system expansion but does not alter conduction system function or promote spontaneous arrhythmias. FASEB J 28:3007-15|
|Yang, Xiulan; Pabon, Lil; Murry, Charles E (2014) Engineering adolescence: maturation of human pluripotent stem cell-derived cardiomyocytes. Circ Res 114:511-23|
|Thomson, Kassandra S; Dupras, Sarah K; Murry, Charles E et al. (2014) Proangiogenic microtemplated fibrin scaffolds containing aprotinin promote improved wound healing responses. Angiogenesis 17:195-205|
|Shiba, Yuji; Filice, Dominic; Fernandes, Sarah et al. (2014) Electrical Integration of Human Embryonic Stem Cell-Derived Cardiomyocytes in a Guinea Pig Chronic Infarct Model. J Cardiovasc Pharmacol Ther 19:368-381|
|Bahrami, Arya J; Gunaje, Jagadambika J; Hayes, Brian J et al. (2014) Regulator of G-protein signaling-5 is a marker of hepatic stellate cells and expression mediates response to liver injury. PLoS One 9:e108505|
Showing the most recent 10 out of 44 publications