The primary goal of this core is to aid the investigators of the individual projects in generation of sufficient numbers of genetically modifled mice to complete their projects in a timely and efficient fashion. The mouse breeding and genotyping core will be responsible for 1) overseeing the generation and characterization of genetically modified mice;2) maintenance, expansion and intercrossing of mice lines as needed;and 3) optimization of genotyping protocols for mice containing multiple recombinant genes.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL095070-05
Application #
8507563
Study Section
Special Emphasis Panel (ZHL1-PPG-A)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
5
Fiscal Year
2013
Total Cost
$384,773
Indirect Cost
$136,751
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Lee, Minyoung; San Martín, Alejandra; Valdivia, Alejandra et al. (2016) Redox-Sensitive Regulation of Myocardin-Related Transcription Factor (MRTF-A) Phosphorylation via Palladin in Vascular Smooth Muscle Cell Differentiation Marker Gene Expression. PLoS One 11:e0153199
Simmons, Rachel D; Kumar, Sandeep; Thabet, Salim Raid et al. (2016) Omics-based approaches to understand mechanosensitive endothelial biology and atherosclerosis. Wiley Interdiscip Rev Syst Biol Med 8:378-401
Montaniel, Kim Ramil C; Harrison, David G (2016) Is Hypertension a Bone Marrow Disease? Circulation 134:1369-1372
Hansen, Laura M; Gupta, Divya; Joseph, Giji et al. (2016) The receptor for advanced glycation end products impairs collateral formation in both diabetic and non-diabetic mice. Lab Invest :
Simmons, Rachel D; Kumar, Sandeep; Jo, Hanjoong (2016) The role of endothelial mechanosensitive genes in atherosclerosis and omics approaches. Arch Biochem Biophys 591:111-31
Griendling, Kathy K; Touyz, Rhian M; Zweier, Jay L et al. (2016) Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association. Circ Res 119:e39-75
Paredes, Felipe; Parra, Valentina; Torrealba, Natalia et al. (2016) HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor. Free Radic Biol Med 90:206-18
Fernández Esmerats, Joan; Heath, Jack; Jo, Hanjoong (2016) Shear-Sensitive Genes in Aortic Valve Endothelium. Antioxid Redox Signal 25:401-14
Di Marco, Elyse; Gray, Stephen P; Kennedy, Kit et al. (2016) NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis. Free Radic Biol Med 97:556-67
Rathan, Swetha; Ankeny, Casey J; Arjunon, Sivakkumar et al. (2016) Identification of side- and shear-dependent microRNAs regulating porcine aortic valve pathogenesis. Sci Rep 6:25397

Showing the most recent 10 out of 91 publications