This Program Project consists of four individual related research projects and three cores. This core oversees the administrative needs of the program. The Program Project director (Dr. Nelson) will maintain a staff who are responsible for financial records, progress reports, internal documents necessary for the functioning of the program project, and basic computer hardware and software support. Given that two subcontracts (Project 2 Subcontract with the University of Washington and Core B Subcontract with Cornell University) are off-site, it will be crucial that communication between the projects and Core members and these external individuals be at its maximum level. Therefore, the Administrative Core will be responsible for fostering electronic means of inter-Project/Core communication and scheduling semi-annual retreats that will assemble all the Pis to discuss the progress of the Program Project. At the University of Vermont, the Administrative Core will schedule the monthly Program Project meeting as well as arrange for the scheduled Internal and External Advisory Committee meetings. The Core will also schedule at least 6 research seminars from internationally recognized scientists outside of the University, whose expertise complements the research interests of the Program Project. The Core will provide secretarial and administrative assistance to the Internal and External Advisory Committee. Manuscripts, progress reports, budgets, personnel recruitment, and assistance with other matters and documents intrinsic to the program will be handled by personnel within the Core. Individual principal investigators are responsible for the scientific progress of the functional units they direct and for utilizing the budgets involved. The Program Project Director will critically review, for approval or disapproval, all significant personnel changes (changes in rank, percent effort, persons involved, etc.), all major shifts of money from one listed in the budget of this proposal.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Heart, Lung, and Blood Initial Review Group (HLBP)
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University of Vermont & St Agric College
United States
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Wallace, Kedra; Tremble, Sarah M; Owens, Michelle Y et al. (2015) Plasma from patients with HELLP syndrome increases blood-brain barrier permeability. Reprod Sci 22:278-84
Cipolla, Marilyn J; Sweet, Julie; Chan, Siu-Lung et al. (2014) Increased pressure-induced tone in rat parenchymal arterioles vs. middle cerebral arteries: role of ion channels and calcium sensitivity. J Appl Physiol (1985) 117:53-9
Longden, Thomas A; Dabertrand, Fabrice; Hill-Eubanks, David C et al. (2014) Stress-induced glucocorticoid signaling remodels neurovascular coupling through impairment of cerebrovascular inwardly rectifying K+ channel function. Proc Natl Acad Sci U S A 111:7462-7
Dunn, Kathryn M; Nelson, Mark T (2014) Neurovascular signaling in the brain and the pathological consequences of hypertension. Am J Physiol Heart Circ Physiol 306:H1-14
Cipolla, Marilyn J; Chan, Siu-Lung; Sweet, Julie et al. (2014) Postischemic reperfusion causes smooth muscle calcium sensitization and vasoconstriction of parenchymal arterioles. Stroke 45:2425-30
Mingin, Gerald C; Peterson, Abbey; Erickson, Cuixia Shi et al. (2014) Social stress induces changes in urinary bladder function, bladder NGF content, and generalized bladder inflammation in mice. Am J Physiol Regul Integr Comp Physiol 307:R893-900
Schreurs, Malou P H; Cipolla, Marilyn J (2014) Cerebrovascular dysfunction and blood-brain barrier permeability induced by oxidized LDL are prevented by apocynin and magnesium sulfate in female rats. J Cardiovasc Pharmacol 63:33-9
Krishnamoorthy, Gayathri; Sonkusare, Swapnil K; Heppner, Thomas J et al. (2014) Opposing roles of smooth muscle BK channels and ryanodine receptors in the regulation of nerve-evoked constriction of mesenteric resistance arteries. Am J Physiol Heart Circ Physiol 306:H981-8
Mercado, Jose; Baylie, Rachael; Navedo, Manuel F et al. (2014) Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle. J Gen Physiol 143:559-75
Hill-Eubanks, David C; Gonzales, Albert L; Sonkusare, Swapnil K et al. (2014) Vascular TRP channels: performing under pressure and going with the flow. Physiology (Bethesda) 29:343-60

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