The Physiology Core (Core B) will support the two human projects that are part of this PPG and will provide state-of-the art technical and participant safety support for the planned studies. This will include {nursing support as well as} salary support for individuals with the technical expertise to conduct the necessary hemodynamic, sympathetic nerve activity (microneurography), and ultrasound-based blood flow measurements in various target tissues (skeletal muscle, renal and coronary circulations). In addition, this Core will provide assistance with conducting invasive pharmacological probes (systemic and regional drug infusions), and for processing of biochemical analyses. {The Physiology Core will also provide the investigators assistance with recruitment, screening and selection of appropriate research participants, central tracking, coordination and scheduling of support personnel and equipment, oversight and monitoring of safety procedures during and following the studies, as well as reporting of adverse events. For clinical safety issues, staff will report to Dr. Leuenberger (Core B Director) who in conjunction with Dr. Boehmer will provide physician oversight of all studies. In our present PPG we have used a similar approach and have found it to greatly facilitate safe and successful completion of a number of complex study protocols.} By coordinating the support functions for all human subprojects of the PPG, by leveraging existing resources in the GCRC, and by facilitating methodological innovation in a collaborative approach, the Core will be able to function in a highly cost effective manner, and will standardize protocols, improve techniques, and thereby ensure optimal data quality and safety of research participants.

Public Health Relevance

This Core will be essential to facilitate all human research protocols of the PPG, to provide quality control for data collection and analysis, and to ensure research participant safety. The human research conducted in this PPG will capitalize on new knowledge gleaned from animal studies, and will directly test its implications in human physiology and in cardiovascular disease.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Heart, Lung, and Blood Initial Review Group (HLBP)
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Pennsylvania State University
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Clark, Christine M; Monahan, Kevin D; Drew, Rachel C (2018) Omega-3 polyunsaturated fatty acid supplementation reduces blood pressure but not renal vasoconstrictor response to orthostatic stress in healthy older adults. Physiol Rep 6:e13674
Drew, Rachel C; Blaha, Cheryl A; Herr, Michael D et al. (2017) Muscle mechanoreflex activation via passive calf stretch causes renal vasoconstriction in healthy humans. Am J Physiol Regul Integr Comp Physiol 312:R956-R964
Cui, Jian; Boehmer, John; Blaha, Cheryl et al. (2017) Muscle sympathetic nerve activity response to heat stress is attenuated in chronic heart failure patients. Am J Physiol Regul Integr Comp Physiol 312:R873-R882
Drew, Rachel C (2017) Baroreflex and neurovascular responses to skeletal muscle mechanoreflex activation in humans: an exercise in integrative physiology. Am J Physiol Regul Integr Comp Physiol 313:R654-R659
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Xing, Jihong; Li, Jianhua (2017) Proteinase-Activated Receptor-2 Sensitivity of Amplified TRPA1 Activity in Skeletal Muscle Afferent Nerves and Exercise Pressor Reflex in Rats with Femoral Artery Occlusion. Cell Physiol Biochem 44:163-171
Xing, Jihong; Li, Jianhua (2016) The Role Played by Adenosine in Modulating Reflex Sympathetic and Pressor Responses Evoked by Stimulation of TRPV1 in Muscle Afferents. Cell Physiol Biochem 40:39-48

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