The Physiology Core (Core B) will support the two human projects that are part of this PPG and will provide state-of-the art technical and participant safety support for the planned studies. This will include {nursing support as well as} salary support for individuals with the technical expertise to conduct the necessary hemodynamic, sympathetic nerve activity (microneurography), and ultrasound-based blood flow measurements in various target tissues (skeletal muscle, renal and coronary circulations). In addition, this Core will provide assistance with conducting invasive pharmacological probes (systemic and regional drug infusions), and for processing of biochemical analyses. {The Physiology Core will also provide the investigators assistance with recruitment, screening and selection of appropriate research participants, central tracking, coordination and scheduling of support personnel and equipment, oversight and monitoring of safety procedures during and following the studies, as well as reporting of adverse events. For clinical safety issues, staff will report to Dr. Leuenberger (Core B Director) who in conjunction with Dr. Boehmer will provide physician oversight of all studies. In our present PPG we have used a similar approach and have found it to greatly facilitate safe and successful completion of a number of complex study protocols.} By coordinating the support functions for all human subprojects of the PPG, by leveraging existing resources in the GCRC, and by facilitating methodological innovation in a collaborative approach, the Core will be able to function in a highly cost effective manner, and will standardize protocols, improve techniques, and thereby ensure optimal data quality and safety of research participants.

Public Health Relevance

This Core will be essential to facilitate all human research protocols of the PPG, to provide quality control for data collection and analysis, and to ensure research participant safety. The human research conducted in this PPG will capitalize on new knowledge gleaned from animal studies, and will directly test its implications in human physiology and in cardiovascular disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL096570-04
Application #
8502540
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$418,162
Indirect Cost
$147,761
Name
Pennsylvania State University
Department
Type
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
Muller, Matthew D; Li, Zhijun; Sica, Christopher T et al. (2016) Muscle oxygenation during dynamic plantar flexion exercise: combining BOLD MRI with traditional physiological measurements. Physiol Rep 4:
Cui, Jian; Blaha, Cheryl; Sinoway, Lawrence I (2016) Whole body heat stress attenuates the pressure response to muscle metaboreceptor stimulation in humans. J Appl Physiol (1985) 121:1178-1186
Li, Zhijun; Muller, Matthew D; Wang, Jianli et al. (2016) Dynamic characteristics of T2*-weighted signal in calf muscles of peripheral artery disease during low-intensity exercise. J Magn Reson Imaging :
Ross, Amanda J; Gao, Zhaohui; Luck, Jonathan Carter et al. (2016) Coronary Exercise Hyperemia Is Impaired in Patients with Peripheral Arterial Disease. Ann Vasc Surg :
Copp, Steven W; Kim, Joyce S; Ruiz-Velasco, Victor et al. (2016) The mechano-gated channel inhibitor GsMTx4 reduces the exercise pressor reflex in decerebrate rats. J Physiol 594:641-55
Clark, Christine M; Monahan, Kevin D; Drew, Rachel C (2016) Omega-3 polyunsaturated fatty acid supplementation attenuates blood pressure increase at onset of isometric handgrip exercise in healthy young and older humans. Physiol Rep 4:
Stone, Audrey J; Kaufman, Marc P (2015) The exercise pressor reflex and peripheral artery disease. Auton Neurosci 188:69-73
Clark, Christine M; Monahan, Kevin D; Drew, Rachel C (2015) Aging augments renal vasoconstrictor response to orthostatic stress in humans. Am J Physiol Regul Integr Comp Physiol 309:R1474-8
Copp, Steven W; Stone, Audrey J; Li, Jianhua et al. (2015) Role played by interleukin-6 in evoking the exercise pressor reflex in decerebrate rats: effect of femoral artery ligation. Am J Physiol Heart Circ Physiol 309:H166-73
Muller, Matthew D; Drew, Rachel C; Ross, Amanda J et al. (2015) Inhibition of cyclooxygenase attenuates the blood pressure response to plantar flexion exercise in peripheral arterial disease. Am J Physiol Heart Circ Physiol 309:H523-8

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