The Physiology Core (Core B) will support the two human projects that are part of this PPG and will provide state-of-the art technical and participant safety support for the planned studies. This will include {nursing support as well as} salary support for individuals with the technical expertise to conduct the necessary hemodynamic, sympathetic nerve activity (microneurography), and ultrasound-based blood flow measurements in various target tissues (skeletal muscle, renal and coronary circulations). In addition, this Core will provide assistance with conducting invasive pharmacological probes (systemic and regional drug infusions), and for processing of biochemical analyses. {The Physiology Core will also provide the investigators assistance with recruitment, screening and selection of appropriate research participants, central tracking, coordination and scheduling of support personnel and equipment, oversight and monitoring of safety procedures during and following the studies, as well as reporting of adverse events. For clinical safety issues, staff will report to Dr. Leuenberger (Core B Director) who in conjunction with Dr. Boehmer will provide physician oversight of all studies. In our present PPG we have used a similar approach and have found it to greatly facilitate safe and successful completion of a number of complex study protocols.} By coordinating the support functions for all human subprojects of the PPG, by leveraging existing resources in the GCRC, and by facilitating methodological innovation in a collaborative approach, the Core will be able to function in a highly cost effective manner, and will standardize protocols, improve techniques, and thereby ensure optimal data quality and safety of research participants.

Public Health Relevance

This Core will be essential to facilitate all human research protocols of the PPG, to provide quality control for data collection and analysis, and to ensure research participant safety. The human research conducted in this PPG will capitalize on new knowledge gleaned from animal studies, and will directly test its implications in human physiology and in cardiovascular disease.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Heart, Lung, and Blood Initial Review Group (HLBP)
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Pennsylvania State University
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Stone, Audrey J; Kaufman, Marc P (2015) The exercise pressor reflex and peripheral artery disease. Auton Neurosci 188:69-73
Cui, Jian; Sinoway, Lawrence I (2014) Cardiovascular responses to heat stress in chronic heart failure. Curr Heart Fail Rep 11:139-45
Solaiman, Adil Z; Feehan, Robert P; Chabitnoy, Amy M et al. (2014) Ventilatory responses to chemoreflex stimulation are not enhanced by angiotensin II in healthy humans. Auton Neurosci 183:72-9
Patel, Hardikkumar M; Heffernan, Matthew J; Ross, Amanda J et al. (2014) Sex differences in forearm vasoconstrictor response to voluntary apnea. Am J Physiol Heart Circ Physiol 306:H309-16
Muller, Matthew D; Gao, Zhaohui; Patel, Hardikkumar M et al. (2014) ?-Adrenergic blockade enhances coronary vasoconstrictor response to forehead cooling. Am J Physiol Heart Circ Physiol 306:H910-7
Copp, Steven W; Stone, Audrey J; Yamauchi, Katsuya et al. (2014) Effects of peripheral and spinal ?-opioid receptor stimulation on the exercise pressor reflex in decerebrate rats. Am J Physiol Regul Integr Comp Physiol 307:R281-9
Yamauchi, Katsuya; Tsuchimochi, Hirotsugu; Stone, Audrey J et al. (2014) Increased dietary salt intake enhances the exercise pressor reflex. Am J Physiol Heart Circ Physiol 306:H450-4
Li, Jianhua; Xing, Jihong; Lu, Jian (2014) Nerve Growth Factor, Muscle Afferent Receptors and Autonomic Responsiveness with Femoral Artery Occlusion. J Mod Physiol Res 1:1-18
Muller, Matthew D; Gao, Zhaohui; McQuillan, Patrick M et al. (2014) Coronary responses to cold air inhalation following afferent and efferent blockade. Am J Physiol Heart Circ Physiol 307:H228-35
Yamauchi, Katsuya; Stone, Audrey J; Kaufman, Marc P (2014) Hindlimb venous distention evokes a pressor reflex in decerebrated rats. Physiol Rep 2:

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