The overall goal of Project 1 is to examine the prognostic significance of mental stress-induced ischemia in a large and contemporary population of CAD patients with and without exercise-induced ischemia, and to examine the role of genetic variations in the a- and ^ff-adrenergic receptor genes and other gene systems known to regulate the reactivity response to stress. Specifically, we propose to address the following aims:
Aim 1 : Among CAD patients with and without exercise-induced ischemia, examine the relationship between mental stress-induced ischemia and adverse outcomes defined as: a) death and myocardial infarction (Ml); and b) a composite index of death, nonfatal Ml, hospitalization for unstable angina, and need for revascularization (coronary bypass surgery or percutaneous intervention). We will test the hypothesis that CAD patients with mental stress-induced ischemia will have higher rates of adverse outcomes than those without mental stress-induced ischemia irrespective of the presence of exercise-induced ischemia.
Aim 2 : Among CAD patients with and without exercise-induced ischemia, examine the relationship between genetic polymorphisms of the a- and;ff-adrenergic receptors and other candidate genes related to the stress response and mental stress-induced ischemia. We will test the hypothesis that these genetic polymorphisms will be associated with mental stress-induced ischemia and thus the allele and/or genotype frequencies in CAD patients without mental stress-induced ischemia will differ from those in patients with mental stress-induced ischemia.
|Kelli, Heval M; Corrigan 3rd, Frank E; Heinl, Robert E et al. (2017) Relation of Changes in Body Fat Distribution to Oxidative Stress. Am J Cardiol 120:2289-2293|
|Hammadah, Muhammad; Al Mheid, Ibhar; Wilmot, Kobina et al. (2017) Association Between High-Sensitivity Cardiac Troponin Levels and Myocardial Ischemia During Mental Stress and Conventional Stress. JACC Cardiovasc Imaging :|
|Samman Tahhan, Ayman; Hammadah, Muhammad; Sandesara, Pratik B et al. (2017) Progenitor Cells and Clinical Outcomes in Patients With Heart Failure. Circ Heart Fail 10:|
|Hayek, Salim S; Ko, Yi-An; Awad, Mosaab et al. (2017) Depression and chest pain in patients with coronary artery disease. Int J Cardiol 230:420-426|
|O'Neal, Wesley T; Hammadah, Muhammad; Sandesara, Pratik B et al. (2017) The association between acute mental stress and abnormal left atrial electrophysiology. J Cardiovasc Electrophysiol 28:1151-1157|
|Reinertsen, Erik; Nemati, Shamim; Vest, Adriana N et al. (2017) Heart rate-based window segmentation improves accuracy of classifying posttraumatic stress disorder using heart rate variability measures. Physiol Meas 38:1061-1076|
|Ghasemzedah, Nima; Hayek, Salim S; Ko, Yi-An et al. (2017) Pathway-Specific Aggregate Biomarker Risk Score Is Associated With Burden of Coronary Artery Disease and Predicts Near-Term Risk of Myocardial Infarction and Death. Circ Cardiovasc Qual Outcomes 10:|
|Vaccarino, Viola; Bremner, J Douglas (2017) Behavioral, emotional and neurobiological determinants of coronary heart disease risk in women. Neurosci Biobehav Rev 74:297-309|
|Humphries, K H; Izadnegahdar, M; Sedlak, T et al. (2017) Sex differences in cardiovascular disease - Impact on care and outcomes. Front Neuroendocrinol 46:46-70|
|Hayek, Salim S; Ko, Yi-An; Awad, Mosaab et al. (2017) Cardiovascular Disease Biomarkers and suPAR in Predicting Decline in Renal Function: A Prospective Cohort Study. Kidney Int Rep 2:425-432|
Showing the most recent 10 out of 44 publications