The Administrative Core will be responsible for coordinating activities among the four Projects and two scientific Core Units, the financial management of the Program, and other administrative responsibilities Specifically, the aims of Core Unit A are: Coordinate formal and informal reviews of the Program and of meefings of Program scientists. Assume responsibility forthe financial management ofthe Program. Provide office, personnel and clerical support. Provide computer support to the Program scientists.

Public Health Relevance

The overall goal ofthis Program Project is to develop a better understanding ofthe mechanisms linking loss of RhoA/Rac 1 balance in the endothelial hyper-permeability associated with acute lung injury (ALI). Emphasis is placed on understanding both novel mechanisnis underlying EC barrier disruption and on developing novel reagents to restore EC barrier funcfion during ALI.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL101902-02
Application #
8376422
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
2
Fiscal Year
2012
Total Cost
$176,568
Indirect Cost
$58,856
Name
Georgia Regents University
Department
Type
DUNS #
966668691
City
Augusta
State
GA
Country
United States
Zip Code
30912
Barabutis, Nektarios; Khangoora, Vikramjit; Marik, Paul E et al. (2017) Hydrocortisone and Ascorbic Acid Synergistically Prevent and Repair Lipopolysaccharide-Induced Pulmonary Endothelial Barrier Dysfunction. Chest 152:954-962
Song, Shanshan; Ayon, Ramon J; Yamamura, Aya et al. (2017) Capsaicin-induced Ca(2+) signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH. Am J Physiol Lung Cell Mol Physiol 312:L309-L325
Wang, Ting; Gross, Christine; Desai, Ankit A et al. (2017) Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets. Am J Physiol Lung Cell Mol Physiol 312:L452-L476
Kumar, Sanjiv; Sun, Xutong; Noonepalle, Satish Kumar et al. (2017) Hyper-activation of pp60Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury. Free Radic Biol Med 102:217-228
Chen, F; Wang, Y; Rafikov, R et al. (2017) RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins. Biochem Pharmacol 127:34-45
Bátori, Róbert; Bécsi, Bálint; Nagy, Dénes et al. (2017) Interplay of myosin phosphatase and protein phosphatase-2A in the regulation of endothelial nitric-oxide synthase phosphorylation and nitric oxide production. Sci Rep 7:44698
Fulton, David J R; Barman, Scott A (2016) Clarity on the Isoform-Specific Roles of NADPH Oxidases and NADPH Oxidase-4 in Atherosclerosis. Arterioscler Thromb Vasc Biol 36:579-81
Rafikova, Olga; Rafikov, Ruslan; Kangath, Archana et al. (2016) Redox regulation of epidermal growth factor receptor signaling during the development of pulmonary hypertension. Free Radic Biol Med 95:96-111
Xie, Lishi; Chiang, Eddie T; Wu, Xiaomin et al. (2016) Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta. PLoS One 11:e0158865
Kovacs-Kasa, Anita; Gorshkov, Boris A; Kim, Kyung-Mi et al. (2016) The protective role of MLCP-mediated ERM dephosphorylation in endotoxin-induced lung injury in vitro and in vivo. Sci Rep 6:39018

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