The Administrative Core will be responsible for coordinating activities among the four Projects and two scientific Core Units, the financial management of the Program, and other administrative responsibilities Specifically, the aims of Core Unit A are: Coordinate formal and informal reviews of the Program and of meefings of Program scientists. Assume responsibility forthe financial management ofthe Program. Provide office, personnel and clerical support. Provide computer support to the Program scientists.

Public Health Relevance

The overall goal ofthis Program Project is to develop a better understanding ofthe mechanisms linking loss of RhoA/Rac 1 balance in the endothelial hyper-permeability associated with acute lung injury (ALI). Emphasis is placed on understanding both novel mechanisnis underlying EC barrier disruption and on developing novel reagents to restore EC barrier funcfion during ALI.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL101902-03
Application #
8508293
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$168,092
Indirect Cost
$56,030
Name
Georgia Regents University
Department
Type
DUNS #
966668691
City
Augusta
State
GA
Country
United States
Zip Code
30912
Sun, Xutong; Kumar, Sanjiv; Sharma, Shruti et al. (2014) Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase. Am J Respir Cell Mol Biol 50:1084-95
Aggarwal, Saurabh; Gross, Christine M; Rafikov, Ruslan et al. (2014) Nitration of tyrosine 247 inhibits protein kinase G-1? activity by attenuating cyclic guanosine monophosphate binding. J Biol Chem 289:7948-61
Gonzales, Joyce N; Gorshkov, Boris; Varn, Matthew N et al. (2014) Protective effect of adenosine receptors against lipopolysaccharide-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol 306:L497-507
Xu, Yiming; An, Xiaofei; Guo, Xin et al. (2014) Endothelial PFKFB3 plays a critical role in angiogenesis. Arterioscler Thromb Vasc Biol 34:1231-9
Gross, Christine M; Aggarwal, Saurabh; Kumar, Sanjiv et al. (2014) Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress. J Cell Physiol 229:1802-16
Chen, Feng; Yu, Yanfang; Haigh, Steven et al. (2014) Regulation of NADPH oxidase 5 by protein kinase C isoforms. PLoS One 9:e88405
Czikora, István; Alli, Abdel; Bao, Hui-Fang et al. (2014) A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation. Am J Respir Crit Care Med 190:522-32
Chen, Feng; Kumar, Sanjiv; Yu, Yanfang et al. (2014) PKC-dependent phosphorylation of eNOS at T495 regulates eNOS coupling and endothelial barrier function in response to G+ -toxins. PLoS One 9:e99823
Gonzales, Joyce N; Kim, Kyung-mi; Zemskova, Marina A et al. (2014) Low anticoagulant heparin blocks thrombin-induced endothelial permeability in a PAR-dependent manner. Vascul Pharmacol 62:63-71
Rafikov, Ruslan; Dimitropoulou, Christiana; Aggarwal, Saurabh et al. (2014) Lipopolysaccharide-induced lung injury involves the nitration-mediated activation of RhoA. J Biol Chem 289:4710-22

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