The Administrative Core will be responsible for coordinating activities among the four Projects and two scientific Core Units, the financial management of the Program, and other administrative responsibilities Specifically, the aims of Core Unit A are: Coordinate formal and informal reviews of the Program and of meefings of Program scientists. Assume responsibility forthe financial management ofthe Program. Provide office, personnel and clerical support. Provide computer support to the Program scientists.

Public Health Relevance

The overall goal ofthis Program Project is to develop a better understanding ofthe mechanisms linking loss of RhoA/Rac 1 balance in the endothelial hyper-permeability associated with acute lung injury (ALI). Emphasis is placed on understanding both novel mechanisnis underlying EC barrier disruption and on developing novel reagents to restore EC barrier funcfion during ALI.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL101902-03
Application #
8508293
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$168,092
Indirect Cost
$56,030
Name
Georgia Regents University
Department
Type
DUNS #
966668691
City
Augusta
State
GA
Country
United States
Zip Code
30912
Kovacs-Kasa, Anita; Kim, Kyung Mi; Cherian-Shaw, Mary et al. (2018) Extracellular adenosine-induced Rac1 activation in pulmonary endothelium: Molecular mechanisms and barrier-protective role. J Cell Physiol 233:5736-5746
Gross, Christine M; Kellner, Manuela; Wang, Ting et al. (2018) LPS-induced Acute Lung Injury Involves NF-?B-mediated Downregulation of SOX18. Am J Respir Cell Mol Biol 58:614-624
Chepurnova, D A; Samoilova, E V; Anisimov, A A et al. (2018) Compounds of IL-6 Receptor Complex during Acute Lung Injury. Bull Exp Biol Med 164:609-611
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Barman, Scott A; Chen, Feng; Li, Xueyi et al. (2018) Galectin-3 Promotes Vascular Remodeling and Contributes to Pulmonary Hypertension. Am J Respir Crit Care Med 197:1488-1492
Barabutis, Nektarios; Dimitropoulou, Christiana; Gregory, Betsy et al. (2018) Wild-type p53 enhances endothelial barrier function by mediating RAC1 signalling and RhoA inhibition. J Cell Mol Med 22:1792-1804
Bátori, Róbert; Bécsi, Bálint; Nagy, Dénes et al. (2017) Interplay of myosin phosphatase and protein phosphatase-2A in the regulation of endothelial nitric-oxide synthase phosphorylation and nitric oxide production. Sci Rep 7:44698
Chen, F; Wang, Y; Rafikov, R et al. (2017) RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins. Biochem Pharmacol 127:34-45
Czikora, Istvan; Alli, Abdel A; Sridhar, Supriya et al. (2017) Epithelial Sodium Channel-? Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction. Front Immunol 8:842
Kumar, Sanjiv; Sun, Xutong; Noonepalle, Satish Kumar et al. (2017) Hyper-activation of pp60Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury. Free Radic Biol Med 102:217-228

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