The Human Clinical Core (Core B) component of this TPPG will provide the clinical expertise and organization necessary to accomplish the studies involving human subjects that are proposed in the projects within this TPPG. The core will be responsible for subject recruitment and communication, clinical specimen collection, subject characterization through clinical data acquisition and subject follow-up. The Clinical Core will interact intimately with the Asthma Biorepository Core C to ensure distribution of clinical samples and data to program investigators. In this capacity, the clinical core will function as a collective resource to the TPPG that will facilitate accomplishment of each of the three projects and also promote interaction between the different projects to glean the most information from valuable clinical samples. Following recruitment, the core will use a variety of clinical parameters to divide subjects into four well-defined subgroups: 1) nonallergic, non-asthmatic normal volunteers, 2) allergic non-asthmatics, 3) non-allergic asthmatics, and 4) allergic asthmatics. The volunteers will undergo a comprehensive evaluation Including pulmonary function testing, allergy skin testing, blood testing and exhaled gas measurements. Select volunteers will also undergo outpatient flexible fiberoptic bronchoscopy. Through this procedure the core will obtain ain/ /ay specimens including mucosal brushings, bronchoalveolar lavage fluid, and endobronchial biopsy tissue. These specimens will allow the core to assess parameters of ainway inflammation and will be further processed by the Asthma Biorepository Core C for use by all four TPPG projects. For all of the studies within the TPPG utilizing human subject samples, the clinical core will be responsible for assuring subject safety, data confidentiality and full regulatory compliance.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1-CSR-A (M1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Cleveland Clinic Lerner
United States
Zip Code
Barnes, Jarrod W; Kucera, Elif T; Tian, Liping et al. (2016) Bone Morphogenic Protein Type 2 Receptor Mutation-Independent Mechanisms of Disrupted Bone Morphogenetic Protein Signaling in Idiopathic Pulmonary Arterial Hypertension. Am J Respir Cell Mol Biol 55:564-575
Erzurum, Serpil C (2016) New Insights in Oxidant Biology in Asthma. Ann Am Thorac Soc 13 Suppl 1:S35-9
Gu, Xiaodong; Huang, Ying; Levison, Bruce S et al. (2016) Identification of Critical Paraoxonase 1 Residues Involved in High Density Lipoprotein Interaction. J Biol Chem 291:1890-904
Reeves, Stephen R; Kaber, Gernot; Sheih, Alyssa et al. (2016) Subepithelial Accumulation of Versican in a Cockroach Antigen-Induced Murine Model of Allergic Asthma. J Histochem Cytochem 64:364-80
Wang, Zeneng; DiDonato, Joseph A; Buffa, Jennifer et al. (2016) Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma. J Biol Chem 291:22118-22135
Zein, Joe G; Menegay, Michelle C; Singer, Mendel E et al. (2016) Cost effectiveness of bronchial thermoplasty in patients with severe uncontrolled asthma. J Asthma 53:194-200
Liu, Fei; Haeger, Christina Mallarino; Dieffenbach, Paul B et al. (2016) Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension. JCI Insight 1:
Asosingh, Kewal; Vasanji, Amit; Tipton, Aaron et al. (2016) Eotaxin-Rich Proangiogenic Hematopoietic Progenitor Cells and CCR3+ Endothelium in the Atopic Asthmatic Response. J Immunol 196:2377-87
Xu, Weiling; Ghosh, Sudakshina; Comhair, Suzy A A et al. (2016) Increased mitochondrial arginine metabolism supports bioenergetics in asthma. J Clin Invest 126:2465-81
Yuan, Yiyuan; Hakimi, Parvin; Kao, Clara et al. (2016) Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans. J Biol Chem 291:1307-19

Showing the most recent 10 out of 105 publications