The purpose of the Animal Model Core (Core D) is to provide a centralized facility in which all of the various animal models of asthma outlined in the Program Project may be performed. Personnel experienced in implementing murine models of asthma in a rigorous and reproducible manner will staff the core. All four Projects will utilize Core D The main responsibilities of the core will be the performance of and analysis of data from murine models of asthma. Specific activities will include: - Antigen sensitization and challenge - Environmental Tobacco Smoke (ETS) exposure - Measurement of Airway Hyperresponsiveness - Analysis of bronchoalveolar lavage (BAL) - Harvest and processing of murine tissue samples - Ensure appropriate storage and inventory of processed murine samples and coordinate their distribution to investigators within the TPPG.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL103453-04
Application #
8686060
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
City
Cleveland
State
OH
Country
United States
Zip Code
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