The purpose of the Animal Model Core (Core D) is to provide a centralized facility in which all of the various animal models of asthma outlined in the Program Project may be performed. Personnel experienced in implementing murine models of asthma in a rigorous and reproducible manner will staff the core. All four Projects will utilize Core D The main responsibilities of the core will be the performance of and analysis of data from murine models of asthma. Specific activities will include: - Antigen sensitization and challenge - Environmental Tobacco Smoke (ETS) exposure - Measurement of Airway Hyperresponsiveness - Analysis of bronchoalveolar lavage (BAL) - Harvest and processing of murine tissue samples - Ensure appropriate storage and inventory of processed murine samples and coordinate their distribution to investigators within the TPPG.

Agency
National Institute of Health (NIH)
Type
Research Program Projects (P01)
Project #
5P01HL103453-04
Application #
8686060
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
City
Cleveland
State
OH
Country
United States
Zip Code
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