The purpose of the Animal Model Core (Core D) is to provide a centralized facility in which all of the various animal models of asthma outlined in the Program Project may be performed. Personnel experienced in implementing murine models of asthma in a rigorous and reproducible manner will staff the core. All four Projects will utilize Core D The main responsibilities of the core will be the performance of and analysis of data from murine models of asthma. Specific activities will include: - Antigen sensitization and challenge - Environmental Tobacco Smoke (ETS) exposure - Measurement of Airway Hyperresponsiveness - Analysis of bronchoalveolar lavage (BAL) - Harvest and processing of murine tissue samples - Ensure appropriate storage and inventory of processed murine samples and coordinate their distribution to investigators within the TPPG.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Special Emphasis Panel (ZHL1)
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Cleveland Clinic Lerner
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Barnes, Jarrod W; Kucera, Elif T; Tian, Liping et al. (2016) Bone Morphogenic Protein Type 2 Receptor Mutation-Independent Mechanisms of Disrupted Bone Morphogenetic Protein Signaling in Idiopathic Pulmonary Arterial Hypertension. Am J Respir Cell Mol Biol 55:564-575
Erzurum, Serpil C (2016) New Insights in Oxidant Biology in Asthma. Ann Am Thorac Soc 13 Suppl 1:S35-9
Gu, Xiaodong; Huang, Ying; Levison, Bruce S et al. (2016) Identification of Critical Paraoxonase 1 Residues Involved in High Density Lipoprotein Interaction. J Biol Chem 291:1890-904
Reeves, Stephen R; Kaber, Gernot; Sheih, Alyssa et al. (2016) Subepithelial Accumulation of Versican in a Cockroach Antigen-Induced Murine Model of Allergic Asthma. J Histochem Cytochem 64:364-80
Wang, Zeneng; DiDonato, Joseph A; Buffa, Jennifer et al. (2016) Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma. J Biol Chem 291:22118-22135
Zein, Joe G; Menegay, Michelle C; Singer, Mendel E et al. (2016) Cost effectiveness of bronchial thermoplasty in patients with severe uncontrolled asthma. J Asthma 53:194-200
Liu, Fei; Haeger, Christina Mallarino; Dieffenbach, Paul B et al. (2016) Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension. JCI Insight 1:
Asosingh, Kewal; Vasanji, Amit; Tipton, Aaron et al. (2016) Eotaxin-Rich Proangiogenic Hematopoietic Progenitor Cells and CCR3+ Endothelium in the Atopic Asthmatic Response. J Immunol 196:2377-87
Xu, Weiling; Ghosh, Sudakshina; Comhair, Suzy A A et al. (2016) Increased mitochondrial arginine metabolism supports bioenergetics in asthma. J Clin Invest 126:2465-81
Yuan, Yiyuan; Hakimi, Parvin; Kao, Clara et al. (2016) Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans. J Biol Chem 291:1307-19

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