Core A: Administration, Timothy A. Springer Dr. Springer as Program Director assumes responsibility for overseeing the quality ofthe program as a whole and promoting interactions within it. Under the Adminstrative Core, Dr. Springer will ensure that the overall objectives of the program are met, as described in the Program Introduction and Statement of Objectives.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL103526-04
Application #
8638062
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$123,751
Indirect Cost
$92,846
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Lin, Fu-Yang; Zhu, Jianghai; Eng, Edward T et al. (2016) β-Subunit Binding Is Sufficient for Ligands to Open the Integrin αIIbβ3 Headpiece. J Biol Chem 291:4537-46
Dev, Jyoti; Park, Donghyun; Fu, Qingshan et al. (2016) Structural basis for membrane anchoring of HIV-1 envelope spike. Science 353:172-5
Fu, Qingshan; Fu, Tian-Min; Cruz, Anthony C et al. (2016) Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor. Mol Cell 61:602-13
Chou, James J; Wang, Jia-huai (2015) Transmembrane signaling: A multiplex problem with converging solutions. Prog Biophys Mol Biol 118:87-8
Finci, L; Zhang, Y; Meijers, R et al. (2015) Signaling mechanism of the netrin-1 receptor DCC in axon guidance. Prog Biophys Mol Biol 118:153-60
Zhu, Jianghai; Zhu, Jieqing; Bougie, Daniel W et al. (2015) Structural basis for quinine-dependent antibody binding to platelet integrin αIIbβ3. Blood 126:2138-45
Chen, Xinping; Zhao, Chunyue; Li, Xiaolong et al. (2015) Terazosin activates Pgk1 and Hsp90 to promote stress resistance. Nat Chem Biol 11:19-25
Xia, Wei; Springer, Timothy A (2014) Metal ion and ligand binding of integrin α5β1. Proc Natl Acad Sci U S A 111:17863-8
Blenner, Mark A; Dong, Xianchi; Springer, Timothy A (2014) Structural basis of regulation of von Willebrand factor binding to glycoprotein Ib. J Biol Chem 289:5565-79
OuYang, Bo; Chou, James J (2014) The minimalist architectures of viroporins and their therapeutic implications. Biochim Biophys Acta 1838:1058-67

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