Core A: Administration, Timothy A. Springer Dr. Springer as Program Director assumes responsibility for overseeing the quality ofthe program as a whole and promoting interactions within it. Under the Adminstrative Core, Dr. Springer will ensure that the overall objectives of the program are met, as described in the Program Introduction and Statement of Objectives.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL103526-04
Application #
8638062
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$123,751
Indirect Cost
$92,846
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Springer, Timothy A (2014) von Willebrand factor, Jedi knight of the bloodstream. Blood 124:1412-25
Liu, Ying; Zhang, Yan; Wang, Jia-Huai (2014) Crystal structure of human Ankyrin G death domain. Proteins 82:3476-82
Blenner, Mark A; Dong, Xianchi; Springer, Timothy A (2014) Structural basis of regulation of von Willebrand factor binding to glycoprotein Ib. J Biol Chem 289:5565-79
OuYang, Bo; Chou, James J (2014) The minimalist architectures of viroporins and their therapeutic implications. Biochim Biophys Acta 1838:1058-67
Yu, Yamei; Schurpf, Thomas; Springer, Timothy A (2013) How natalizumab binds and antagonizes *4 integrins. J Biol Chem 288:32314-25
Yu, Yamei; Zhu, Jianghai; Huang, Po-Ssu et al. (2013) Domain 1 of mucosal addressin cell adhesion molecule has an I1-set fold and a flexible integrin-binding loop. J Biol Chem 288:6284-94
Zhu, Jieqing; Zhu, Jianghai; Springer, Timothy A (2013) Complete integrin headpiece opening in eight steps. J Cell Biol 201:1053-68
Wang, Rui; Zhu, Jianghai; Dong, Xianchi et al. (2012) GARP regulates the bioavailability and activation of TGFýý. Mol Biol Cell 23:1129-39
Eng, Edward T; Smagghe, Benoit J; Walz, Thomas et al. (2011) Intact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopy. J Biol Chem 286:35218-26