1. Core Mission and Objectives The broad range of investigations encompassed within this PPG, including genetics, gene expression analysis, and DNA methylation studies in humans and mice, requires careful coordination and communication. Core D (Administration) will coordinate all of the administrative and research activities of the Functional Genetics of COPD Program Project Grant. In this role. Core D will be charged with achieving the following objectives: 1) To provide administrative and logistical support for all three projects and four cores of the PPG 2) To facilitate, monitor, and record the planning activities and research progress in the PPG 3) To coordinate and monitor all administrative activities between the participating PPG institutions: Brigham and Women's Hospital, Harvard School of Public Health, Dana-Farber Cancer Institute, and Temple University 4) To coordinate all PPG educational and dissemination activities

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
1P01HL105339-01A1
Application #
8210655
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2011-08-17
Budget End
2012-06-30
Support Year
1
Fiscal Year
2011
Total Cost
$96,760
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Wang, Xiaoyun; Polverino, Francesca; Rojas-Quintero, Joselyn et al. (2018) A Disintegrin and A Metalloproteinase-9 (ADAM9): A Novel Proteinase Culprit with Multifarious Contributions to COPD. Am J Respir Crit Care Med :
Lopes-Ramos, Camila M; Kuijjer, Marieke L; Ogino, Shuji et al. (2018) Gene Regulatory Network Analysis Identifies Sex-Linked Differences in Colon Cancer Drug Metabolism. Cancer Res 78:5538-5547
Morrow, Jarrett D; Glass, Kimberly; Cho, Michael H et al. (2018) Human Lung DNA Methylation Quantitative Trait Loci Colocalize with Chronic Obstructive Pulmonary Disease Genome-Wide Association Loci. Am J Respir Crit Care Med 197:1275-1284
Hayden, Lystra P; Hardin, Megan E; Qiu, Weiliang et al. (2018) Asthma Is a Risk Factor for Respiratory Exacerbations Without Increased Rate of Lung Function Decline: Five-Year Follow-up in Adult Smokers From the COPDGene Study. Chest 153:368-377
Sharma, Amitabh; Kitsak, Maksim; Cho, Michael H et al. (2018) Integration of Molecular Interactome and Targeted Interaction Analysis to Identify a COPD Disease Network Module. Sci Rep 8:14439
Qiu, Weiliang; Guo, Feng; Glass, Kimberly et al. (2018) Differential connectivity of gene regulatory networks distinguishes corticosteroid response in asthma. J Allergy Clin Immunol 141:1250-1258
Budoff, Matthew J; Lutz, Sharon M; Kinney, Gregory L et al. (2018) Coronary Artery Calcium on Noncontrast Thoracic Computerized Tomography Scans and All-Cause Mortality. Circulation 138:2437-2438
Polverino, Francesca; Rojas-Quintero, Joselyn; Wang, Xiaoyun et al. (2018) A Disintegrin and Metalloproteinase Domain-8: A Novel Protective Proteinase in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 198:1254-1267
Sharma, Amitabh; Halu, Arda; Decano, Julius L et al. (2018) Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes. NPJ Syst Biol Appl 4:25
Hayden, Lystra P; Cho, Michael H; Raby, Benjamin A et al. (2018) Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study. Respir Res 19:209

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