1. Core Mission and Objectives The broad range of investigations encompassed within this PPG, including genetics, gene expression analysis, and DNA methylation studies in humans and mice, requires careful coordination and communication. Core D (Administration) will coordinate all of the administrative and research activities of the Functional Genetics of COPD Program Project Grant. In this role. Core D will be charged with achieving the following objectives: 1) To provide administrative and logistical support for all three projects and four cores of the PPG 2) To facilitate, monitor, and record the planning activities and research progress in the PPG 3) To coordinate and monitor all administrative activities between the participating PPG institutions: Brigham and Women's Hospital, Harvard School of Public Health, Dana-Farber Cancer Institute, and Temple University 4) To coordinate all PPG educational and dissemination activities

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL105339-03
Application #
8501663
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$161,608
Indirect Cost
$114,143
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
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Hersh, Craig P; Make, Barry J; Lynch, David A et al. (2014) Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus. BMC Pulm Med 14:164
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Zhou, XueZhong; Menche, Jörg; Barabási, Albert-László et al. (2014) Human symptoms-disease network. Nat Commun 5:4212
Mizumura, Kenji; Cloonan, Suzanne M; Nakahira, Kiichi et al. (2014) Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD. J Clin Invest 124:3987-4003
Hobbs, Brian D; Hersh, Craig P (2014) Integrative genomics of chronic obstructive pulmonary disease. Biochem Biophys Res Commun 452:276-86
Chu, Jen-hwa; Hersh, Craig P; Castaldi, Peter J et al. (2014) Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD. BMC Syst Biol 8:78
Lee, Jin Hwa; McDonald, Merry-Lynn N; Cho, Michael H et al. (2014) DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease. Respir Res 15:97
Cloonan, Suzanne M; Lam, Hilaire C; Ryter, Stefan W et al. (2014) "Ciliophagy": The consumption of cilia components by autophagy. Autophagy 10:532-4

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