Core B is designed to specifically support the development of """"""""translational glycobiologists"""""""", possessing a firm glycoscience-based mechanistic orientation to medically-oriented issues. By intent, we seek to train individuals that, by virtue of this PEG, will possess broad-based knowledge of glycan chemistry and biochemistry coupled with the motivation and preparafion to apply this considerable glycoscience knowledge to drive fonward the development of transformative therapeutics for heart, lung and blood diseases. To achieve this goal, the Core will provide training that seamlessly incorporates practical skills experience with glycoscience education altogether with bioscience education and the greater appreciation of human physiology, human health and human welfare. By hosfing relevant seminars, this Core will also serve to bridge the ever-widening gap between the glycoscience community and practicing clinicians.

Public Health Relevance

Core B will provide training that seamlessly incorporates practical skills experience with glycoscience education altogether with bioscience education and the greater appreciation of human physiology, human health and human welfare.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
1P01HL107146-01
Application #
8183657
Study Section
Special Emphasis Panel (ZHL1-CSR-H (F1))
Project Start
Project End
Budget Start
2011-07-01
Budget End
2012-05-31
Support Year
1
Fiscal Year
2011
Total Cost
$178,137
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
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Dougher, Christopher W L; Buffone Jr, Alexander; Nemeth, Michael J et al. (2017) The blood-borne sialyltransferase ST6Gal-1 is a negative systemic regulator of granulopoiesis. J Leukoc Biol 102:507-516
Lee, Jungmin; Dykstra, Brad; Spencer, Joel A et al. (2017) mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors. J Clin Invest 127:2433-2437

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