This project is a component of the Lung Inflammatory Disease program of the Programs of Excellence in Glycosciences (LID-PEG). In this project we seel

Public Health Relevance

This project seeks to develop novel cell targeted nanoparticles that can deliver agents to white blood cells for diagnosis and treatment of lung and cardiovascular diseases.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL107151-03
Application #
8477253
Study Section
Special Emphasis Panel (ZHL1-CSR-H)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
3
Fiscal Year
2013
Total Cost
$420,505
Indirect Cost
$477
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Stowell, Sean R; Arthur, Connie M; McBride, Ryan et al. (2014) Microbial glycan microarrays define key features of host-microbial interactions. Nat Chem Biol 10:470-6
Kawasaki, Norihito; Rillahan, Cory D; Cheng, Tan-Yun et al. (2014) Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation. J Immunol 193:1560-6
Kiwamoto, Takumi; Brummet, Mary E; Wu, Fan et al. (2014) Mice deficient in the St3gal3 gene product *2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation. J Allergy Clin Immunol 133:240-7.e1-3
Macauley, Matthew S; Crocker, Paul R; Paulson, James C (2014) Siglec-mediated regulation of immune cell function in disease. Nat Rev Immunol 14:653-66
Cho, Seok Hyun; Oh, Sun Young; Lane, Andrew P et al. (2014) Regulation of nasal airway homeostasis and inflammation in mice by SHP-1 and Th2/Th1 signaling pathways. PLoS One 9:e103685
Fang, Ping; Zhou, Li; Zhou, Yuqi et al. (2014) Immune modulatory effects of IL-22 on allergen-induced pulmonary inflammation. PLoS One 9:e107454
Nix, David B; Kumagai, Tadahiro; Katoh, Toshihiko et al. (2014) Improved in-gel reductive ?-elimination for comprehensive O-linked and sulfo-glycomics by mass spectrometry. J Vis Exp :e51840
Rillahan, Cory D; Macauley, Matthew S; Schwartz, Erik et al. (2014) Disubstituted Sialic Acid Ligands Targeting Siglecs CD33 and CD22 Associated with Myeloid Leukaemias and B Cell Lymphomas. Chem Sci 5:2398-2406
Kiwamoto, Takumi; Katoh, Toshihiko; Tiemeyer, Michael et al. (2013) The role of lung epithelial ligands for Siglec-8 and Siglec-F in eosinophilic inflammation. Curr Opin Allergy Clin Immunol 13:106-11
Rillahan, Cory D; Schwartz, Erik; Rademacher, Christoph et al. (2013) On-chip synthesis and screening of a sialoside library yields a high affinity ligand for Siglec-7. ACS Chem Biol 8:1417-22

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