The Chemistry and Biology of Heparan Sulfate'program project consists of several supporting Cores. This document describes the 'Glycoscience Skills Development Core'. This Core will be headed by Drs. Desai and Balagurunathan with each project leader playing an important role in the establishment and operation of the core. The PLs will form the primary body that co-ordinates efforts on the development of skills. At least six scientists, some already engaged in research with the Pis, will form the focus group for glycoscience skills engagement. These six individuals will work under the direct supervision of their PLs. In addition, the PLs will train new graduate and postdoctoral students. Finally, the six senior scientists will be expected to engage additional junior members (post-doctoral, graduate or undergraduate students) of the laboratory so as to cultivate supervisory skills for a future independent faculty position. Overall, the four teams of the PEG expect to train six senior scientists and 10 new students (postdoctoral and graduate) in glycoscience research. The Core will organize a yearly glycan skills boot camp, didactic teaching sessions, workshops on research and teaching techniques, workshop on proposal writing and reviewing, and train participants in responsible conduct of research. Among the glycan skills that will be specifically taught include the glycan isolation, separation and preparation skills, glycan structure and analysis skills, glycan molecular modeling and simulation skills, glycan biophysical and biochemical interactions skills, glycan biology skills and glycan histopathology and immunology skills.
The Glycan Skills Development Core will support the The Chemistry and Biology of Heparan Sulfate'program project on all aspects of skills development. The PEG proposes design of heparan sulfate molecules that are potentially useful in the treatment of thrombotic and inflammatory disorders as well as resolve coagulation problems observed in during pig to non-human primate xenotransplantation.
|Ezzelarab, Mohamed B; Ekser, Burcin; Azimzadeh, Agnes et al. (2015) Systemic inflammation in xenograft recipients precedes activation of coagulation. Xenotransplantation 22:32-47|
|Sepuru, Krishna Mohan; Poluri, Krishna Mohan; Rajarathnam, Krishna (2014) Solution structure of CXCL5--a novel chemokine and adipokine implicated in inflammation and obesity. PLoS One 9:e93228|
|Mehta, Akul Y; Thakkar, Jay N; Mohammed, Bassem M et al. (2014) Targeting the GPIb? binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effects. J Med Chem 57:3030-9|
|Bane Jr, Charles E; Gailani, David (2014) Factor XI as a target for antithrombotic therapy. Drug Discov Today 19:1454-8|
|Kalita, Mausam; Balivada, Sivasai; Swarup, Vimal Paritosh et al. (2014) A nanosensor for ultrasensitive detection of oversulfated chondroitin sulfate contaminant in heparin. J Am Chem Soc 136:554-7|
|Rajarathnam, Krishna; Rosgen, Jorg (2014) Isothermal titration calorimetry of membrane proteins - progress and challenges. Biochim Biophys Acta 1838:69-77|
|Tran, Vy M; Kuberan, Balagurunathan (2014) Synthesis of fluorophore-tagged xylosides that prime glycosaminoglycan chains. Bioconjug Chem 25:262-8|
|Safo, Martin K; Musayev, Faik N; Mosier, Philip D et al. (2014) Crystal structures of influenza A virus matrix protein M1: variations on a theme. PLoS One 9:e109510|
|Al-Horani, Rami A; Desai, Umesh R (2014) Designing allosteric inhibitors of factor XIa. Lessons from the interactions of sulfated pentagalloylglucopyranosides. J Med Chem 57:4805-18|
|Al-Horani, Rami A; Desai, Umesh R (2014) Recent advances on plasmin inhibitors for the treatment of fibrinolysis-related disorders. Med Res Rev 34:1168-216|
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