Core A: Administrative Core - Gerald W. Hart, Core Director The Administrative Core will have several overall functions: 1) Provide all logistic support for all PEG activities;2) Coordinate activities within the Program and between the Program and the Administrative Center;3) Serve as the central contact point for the Shared Resources Core;4) Organize and plan meetings with the external and internal advisory committees;5) Help with the logistics, organization and operation of the Glycosciences Skills Development Course;6) Resolve and track budgetary issues and provide each Project and Core with monthly reports on their fiscal status. 7) Oversee the applications, review process and provide logistic support to the Internal Advisory Committee in their annual selection of a """"""""CardioGlycoBiologist"""""""" Postdoctoral Fellow by a peer-reviewed competitive process. In order to provide more funds for the actual research and teaching mission of the PEG, the salary support requested for this Core by the Core Director and his Administrative Assistant have been kept small. However, this Core and the PEG will have the direct expert help of the Administrative Office of the Department of Biological Chemistry, which includes our Administrator, an Administrative Manager, two budget analysts, and two full time secretaries. These individuals all report directly to Dr. Hart. The Administrative Core will schedule and provide logistic support for the bi-weekly meetings of the Project and Core Leaders. It will schedule and coordinate the Monthly evening """"""""pizza"""""""" research meetings in which Project and Core members will present their research progress. The Core will monitor participation by all members of the PEG in these activities to ensure the PEG mission is met. In addition, Biological Chemistry will continue to provide the venue and support for the Baltimore/Washington Glycobiology Interest Group (GIG) Meetings, which have been meeting here (generally 30 to 50 people/month) for many years. The Core will ensure that all reports required by NHLBI are done on time and in the correct format. Drs. Hart Zachara and van Eyk will ensure that the Biol. Chemistry seminar program invites at-least 4 glycoscientists per year who may also present at the Baltimore/Washington GIG meetings. The Core will organize and provide logistical support for an annual retreat with oral and poster presentations by all PEG participants, which will be coordinated with the annual review by our external review panel of leading glycoscientists. This PEG will not only advance our understanding of the roles of glycoconjugates in cardiovascular disease, but also will enhance the visibility of the field at JHUSOM, especially to cardiologists.

Public Health Relevance

This Program of Excellence in Glycosciences (PEG) will establish a synergistic team of scientists to elucidate the various roles of glycoconjugates in cardiac function and disease. This Administrative Core will provide the essential logistical, fiscal, administrative, and coordination necessary to engender and facilitate productive interactions and collaborations that will allow the researchers to focus on science and not be distracted by administrative issues.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Special Emphasis Panel (ZHL1-CSR-H (F1))
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Johns Hopkins University
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Ma, Junfeng; Hart, Gerald W (2017) Analysis of Protein O-GlcNAcylation by Mass Spectrometry. Curr Protoc Protein Sci 87:24.10.1-24.10.16
Zhou, Jianliang; Yang, Weiming; Hu, Yingwei et al. (2017) Site-Specific Fucosylation Analysis Identifying Glycoproteins Associated with Aggressive Prostate Cancer Cell Lines Using Tandem Affinity Enrichments of Intact Glycopeptides Followed by Mass Spectrometry. Anal Chem 89:7623-7630
Yang, Shuang; Zhang, Lei; Thomas, Stefani et al. (2017) Modification of Sialic Acids on Solid Phase: Accurate Characterization of Protein Sialylation. Anal Chem 89:6330-6335
Lagerlöf, Olof; Hart, Gerald W; Huganir, Richard L (2017) O-GlcNAc transferase regulates excitatory synapse maturity. Proc Natl Acad Sci U S A 114:1684-1689
Grima, Jonathan C; Daigle, J Gavin; Arbez, Nicolas et al. (2017) Mutant Huntingtin Disrupts the Nuclear Pore Complex. Neuron 94:93-107.e6
Martinez, Marissa R; Dias, Thiago Braido; Natov, Peter S et al. (2017) Stress-induced O-GlcNAcylation: an adaptive process of injured cells. Biochem Soc Trans 45:237-249
Cho, Gun-Sik; Lee, Dong I; Tampakakis, Emmanouil et al. (2017) Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy. Cell Rep 18:571-582
Groves, Jennifer A; Maduka, Austin O; O'Meally, Robert N et al. (2017) Fatty acid synthase inhibits the O-GlcNAcase during oxidative stress. J Biol Chem 292:6493-6511
Yang, Shuang; Clark, David; Liu, Yang et al. (2017) High-throughput analysis of N-glycans using AutoTip via glycoprotein immobilization. Sci Rep 7:10216
Geno, K Aaron; Bush, C Allen; Wang, Mengnan et al. (2017) WciG O-Acetyltransferase Functionality Differentiates Pneumococcal Serotypes 35C and 42. J Clin Microbiol 55:2775-2784

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