Core A: Administrative Core - Gerald W. Hart, Core Director The Administrative Core will have several overall functions: 1) Provide all logistic support for all PEG activities;2) Coordinate activities within the Program and between the Program and the Administrative Center;3) Serve as the central contact point for the Shared Resources Core;4) Organize and plan meetings with the external and internal advisory committees;5) Help with the logistics, organization and operation of the Glycosciences Skills Development Course;6) Resolve and track budgetary issues and provide each Project and Core with monthly reports on their fiscal status. 7) Oversee the applications, review process and provide logistic support to the Internal Advisory Committee in their annual selection of a """"""""CardioGlycoBiologist"""""""" Postdoctoral Fellow by a peer-reviewed competitive process. In order to provide more funds for the actual research and teaching mission of the PEG, the salary support requested for this Core by the Core Director and his Administrative Assistant have been kept small. However, this Core and the PEG will have the direct expert help of the Administrative Office of the Department of Biological Chemistry, which includes our Administrator, an Administrative Manager, two budget analysts, and two full time secretaries. These individuals all report directly to Dr. Hart. The Administrative Core will schedule and provide logistic support for the bi-weekly meetings of the Project and Core Leaders. It will schedule and coordinate the Monthly evening """"""""pizza"""""""" research meetings in which Project and Core members will present their research progress. The Core will monitor participation by all members of the PEG in these activities to ensure the PEG mission is met. In addition, Biological Chemistry will continue to provide the venue and support for the Baltimore/Washington Glycobiology Interest Group (GIG) Meetings, which have been meeting here (generally 30 to 50 people/month) for many years. The Core will ensure that all reports required by NHLBI are done on time and in the correct format. Drs. Hart Zachara and van Eyk will ensure that the Biol. Chemistry seminar program invites at-least 4 glycoscientists per year who may also present at the Baltimore/Washington GIG meetings. The Core will organize and provide logistical support for an annual retreat with oral and poster presentations by all PEG participants, which will be coordinated with the annual review by our external review panel of leading glycoscientists. This PEG will not only advance our understanding of the roles of glycoconjugates in cardiovascular disease, but also will enhance the visibility of the field at JHUSOM, especially to cardiologists.

Public Health Relevance

This Program of Excellence in Glycosciences (PEG) will establish a synergistic team of scientists to elucidate the various roles of glycoconjugates in cardiac function and disease. This Administrative Core will provide the essential logistical, fiscal, administrative, and coordination necessary to engender and facilitate productive interactions and collaborations that will allow the researchers to focus on science and not be distracted by administrative issues.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
1P01HL107153-01
Application #
8183684
Study Section
Special Emphasis Panel (ZHL1-CSR-H (F1))
Project Start
2011-07-01
Project End
2018-05-31
Budget Start
2011-07-01
Budget End
2012-05-31
Support Year
1
Fiscal Year
2011
Total Cost
$106,469
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Harosh-Davidovich, Shani Ben; Khalaila, Isam (2018) O-GlcNAcylation affects ?-catenin and E-cadherin expression, cell motility and tumorigenicity of colorectal cancer. Exp Cell Res 364:42-49
Drake, Walter R; Hou, Ching-Wen; Zachara, Natasha E et al. (2018) New use for CETSA: monitoring innate immune receptor stability via post-translational modification by OGT. J Bioenerg Biomembr 50:231-240
Höti, Naseruddin; Yang, Shuang; Hu, Yingwei et al. (2018) Overexpression of ? (1,6) fucosyltransferase in the development of castration-resistant prostate cancer cells. Prostate Cancer Prostatic Dis 21:137-146
Hashimoto, Toru; Kim, Grace E; Tunin, Richard S et al. (2018) Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition. Circulation 138:1974-1987
Rainer, Peter P; Dong, Peihong; Sorge, Matteo et al. (2018) Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure. Circ Res 122:e75-e83
Höti, Naseruddin; Shah, Punit; Hu, Yingwei et al. (2017) Proteomics analyses of prostate cancer cells reveal cellular pathways associated with androgen resistance. Proteomics 17:
Ma, Junfeng; Hart, Gerald W (2017) Analysis of Protein O-GlcNAcylation by Mass Spectrometry. Curr Protoc Protein Sci 87:24.10.1-24.10.16
Zhou, Jianliang; Yang, Weiming; Hu, Yingwei et al. (2017) Site-Specific Fucosylation Analysis Identifying Glycoproteins Associated with Aggressive Prostate Cancer Cell Lines Using Tandem Affinity Enrichments of Intact Glycopeptides Followed by Mass Spectrometry. Anal Chem 89:7623-7630
Yang, Shuang; Höti, Naseruddin; Yang, Weiming et al. (2017) Simultaneous analyses of N-linked and O-linked glycans of ovarian cancer cells using solid-phase chemoenzymatic method. Clin Proteomics 14:3
Geno, K Aaron; Bush, C Allen; Wang, Mengnan et al. (2017) WciG O-Acetyltransferase Functionality Differentiates Pneumococcal Serotypes 35C and 42. J Clin Microbiol 55:2775-2784

Showing the most recent 10 out of 137 publications