The Human Subjects Core will provide a core resource for the recruitment and characterization of human subjects and the careful collection of biospecimens from these subjects. Recruiting human subjects for mechanism-oriented clinical research protocols requires well-developed systems to ensure successful subject recruitment and the collection of high quality biospecimens from well-characterized human subjects. Dr John Fahy, director of the UCSF Airway Clinical Research Center (UCSF-ACRC), and Dr Prescott Woodruff (associate director of the UCSF-ACRC), along with a team of research coordinators, have considerable experience in all aspects of these systems. The core will have three specific Aims.
Aim 1 will be to recruit and enroll healthy and asthmatic subjects for study protocols designed to support the need of the three PPG projects.
Aim 2 will be to collect high quality biospecimens from healthy and asthmatic subjects using systems and methods which ensure compliance with regulations.
Aim 3 will be to manage IRB-related approvals and other regulatory paperwork for human research related to the three projects.
Core B will provide a resource for recruiting healthy and asthmatic subjects to clinical studies which will support the projects in this PPG. The core will collect high quality biospecimens from well-characterized healthy and asthmatic subjects using systems and methods which ensure compliance with regulations. The core will also manage IRB-related approvals and other regulatory paperwork for human research related to the three projects.
Ricardo-Gonzalez, Roberto R; Van Dyken, Steven J; Schneider, Christoph et al. (2018) Tissue signals imprint ILC2 identity with anticipatory function. Nat Immunol 19:1093-1099 |
Pavord, Ian D; Beasley, Richard; Agusti, Alvar et al. (2018) After asthma: redefining airways diseases. Lancet 391:350-400 |
Lachowicz-Scroggins, Marrah E; Gordon, Erin D; Wesolowska-Andersen, Agata et al. (2018) Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity. Cell Discov 4:7 |
Bhakta, Nirav R; Christenson, Stephanie A; Nerella, Srilaxmi et al. (2018) IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma. Am J Respir Crit Care Med 197:313-324 |
Peters, Michael C; Ringel, Lando; Dyjack, Nathan et al. (2018) A Transcriptomic Method to Determine Airway Immune Dysfunction in T2-High and T2-Low Asthma. Am J Respir Crit Care Med : |
Wong-McGrath, Kelly; Denlinger, Loren C; Bleecker, Eugene R et al. (2018) Internet-Based Monitoring in the Severe Asthma Research Program Identifies a Subgroup of Patients With Labile Asthma Control. Chest 153:378-386 |
Van Dyken, Steven J; Locksley, Richard M (2018) Chitins and chitinase activity in airway diseases. J Allergy Clin Immunol 142:364-369 |
Dunican, Eleanor M; Elicker, Brett M; Gierada, David S et al. (2018) Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction. J Clin Invest 128:997-1009 |
Fassett, Marlys S; Pua, Heather H; Simpson, Laura J et al. (2018) Identification of Functionally Relevant microRNAs in the Regulation of Allergic Inflammation. Methods Mol Biol 1799:341-351 |
Schneider, Christoph; O'Leary, Claire E; von Moltke, Jakob et al. (2018) A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling. Cell 174:271-284.e14 |
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