The purpose of this Core is to perform ischemia models in the mouse lines for the Program and analyze physiological and microscopic assessments following ischemia. The function of this Core is significant because all four Projects will perform in vivo ischemia models using mice as the outcomes of their proposed studies. It is important to note that the work of this Core will allow the participating laboratories to concentrate their efforts on conducting Specific Aims without spending time on performing ischemia models and analyzing mice used in each Project. In addition, a critical role of this Core for the Program is to avoid the variability of ischemic surgeries performed in each Project. Thus, this essential service will free Program members to conduct the experiments that are the backbone of this proposal.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL108795-04
Application #
8661262
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
4
Fiscal Year
2014
Total Cost
$207,849
Indirect Cost
$71,674
Name
Northwestern University at Chicago
Department
Type
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Kishore, Raj; Khan, Mohsin (2016) More Than Tiny Sacks: Stem Cell Exosomes as Cell-Free Modality for Cardiac Repair. Circ Res 118:330-43
Bharat, Ankit; Bhorade, Sangeeta M; Morales-Nebreda, Luisa et al. (2016) Flow Cytometry Reveals Similarities Between Lung Macrophages in Humans and Mice. Am J Respir Cell Mol Biol 54:147-9
Preslar, Adam T; Tantakitti, Faifan; Park, Kitae et al. (2016) (19)F Magnetic Resonance Imaging Signals from Peptide Amphiphile Nanostructures Are Strongly Affected by Their Shape. ACS Nano 10:7376-84
Archer, Amy M; Saber, Rana; Rose, Shawn et al. (2016) ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model. J Transl Med 14:170
Nicholls, Francesca J; Rotz, Matthew W; Ghuman, Harmanvir et al. (2016) DNA-gadolinium-gold nanoparticles for in vivo T1 MR imaging of transplanted human neural stem cells. Biomaterials 77:291-306
Nagpal, Varun; Rai, Rahul; Place, Aaron T et al. (2016) Response to Letter Regarding Article, ""MiR-125b Is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis"". Circulation 133:e714
Nagpal, Varun; Rai, Rahul; Place, Aaron T et al. (2016) MiR-125b Is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis. Circulation 133:291-301
Verma, Suresh K; Garikipati, Venkata Naga Srikanth; Krishnamurthy, Prasanna et al. (2016) IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation. PLoS One 11:e0147615
Jeyabal, Prince; Thandavarayan, Rajarajan A; Joladarashi, Darukeshwara et al. (2016) MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1. Biochem Biophys Res Commun 471:423-9
Chang, Hsiang-Chun; Wu, Rongxue; Shang, Meng et al. (2016) Reduction in mitochondrial iron alleviates cardiac damage during injury. EMBO Mol Med 8:247-67

Showing the most recent 10 out of 99 publications