The purpose of the molecular probes and imaging core is 1: to synthesize imaging probes (opfical, MR and multimodal) capable of cell tracking, fate mapping, and reporting on molecular events, and 2: to supply imaging expertise and equipment to detect these probes in vivo and in vitro. The four projects within the PPG share a number of interrelated goals in terms of functional and molecular imaging. The purpose of the imaging core is to provide a centralized source of chemical and imaging expertise to the investigators of the PPG, and to develop imaging protocols and techniques that will benefit all the investigators and reduce the amount of redundant effort needed to achieve the imaging goals of the projects.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Heart, Lung, and Blood Initial Review Group (HLBP)
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Northwestern University at Chicago
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Rubert Pérez, Charles M; Stephanopoulos, Nicholas; Sur, Shantanu et al. (2015) The powerful functions of peptide-based bioactive matrices for regenerative medicine. Ann Biomed Eng 43:501-14
Wu, Rongxue; Chang, Hsiang-Chun; Khechaduri, Arineh et al. (2014) Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy. J Clin Invest 124:4795-806
Ardehali, Hossein (2014) How to write a successful grant application and research paper. Circ Res 114:1231-4
Misharin, Alexander V; Cuda, Carla M; Saber, Rana et al. (2014) Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice. Cell Rep 9:591-604
Khare, Sonal; Ratsimandresy, Rojo A; de Almeida, Lúcia et al. (2014) The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. Nat Immunol 15:343-53
Bayeva, Marina; Sawicki, Konrad Teodor; Butler, Javed et al. (2014) Molecular and cellular basis of viable dysfunctional myocardium. Circ Heart Fail 7:680-91
Ichikawa, Yoshihiko; Ghanefar, Mohsen; Bayeva, Marina et al. (2014) Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation. J Clin Invest 124:617-30
Eren, Mesut; Boe, Amanda E; Murphy, Sheila B et al. (2014) PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. Proc Natl Acad Sci U S A 111:7090-5
Tongers, Jörn; Webber, Matthew J; Vaughan, Erin E et al. (2014) Enhanced potency of cell-based therapy for ischemic tissue repair using an injectable bioactive epitope presenting nanofiber support matrix. J Mol Cell Cardiol 74:231-9
Boekhoven, Job; Stupp, Samuel I (2014) 25th anniversary article: supramolecular materials for regenerative medicine. Adv Mater 26:1642-59

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