Lung transplantation currently represents the only cure for a number of advanced lung diseases. Unfortunately, it is also the least successful solid organ transplant because of the very high incidence of BOS which affects >50% of lung transplant recipients in 5 years (18). Poor outcomes in lung transplantation may be intimately related to the tenuous circulation supplying the airways (4, 5, 19). Given the link between loss of microvascular integrity and chronic rejection, the development of adjunctive vasculoprotective therapies, such as those described in this proposal, hold promise for significantly improving outcomes in lung transplantation.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL108797-03
Application #
8484435
Study Section
Special Emphasis Panel (ZHL1-PPG-A)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
3
Fiscal Year
2013
Total Cost
$311,646
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Nicolls, Mark R; Hsu, Joe L; Jiang, Xinguo (2016) Microvascular injury after lung transplantation. Curr Opin Organ Transplant 21:279-84
Maron, Bradley A; Hess, Edward; Maddox, Thomas M et al. (2016) Association of Borderline Pulmonary Hypertension With Mortality and Hospitalization in a Large Patient Cohort: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program. Circulation 133:1240-8
Jiang, X; Nguyen, T T; Tian, W et al. (2015) Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute Rejection. Am J Transplant 15:1768-81
Haddad, François; Spruijt, Onno A; Denault, Andre Y et al. (2015) Right Heart Score for Predicting Outcome in Idiopathic, Familial, or Drug- and Toxin-Associated Pulmonary Arterial Hypertension. JACC Cardiovasc Imaging 8:627-38
Spiekerkoetter, Edda; Sung, Yon K; Sudheendra, Deepti et al. (2015) Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension. Am J Respir Crit Care Med 192:254-7
Hilgendorff, Anne; Parai, Kakoli; Ertsey, Robert et al. (2015) Lung matrix and vascular remodeling in mechanically ventilated elastin haploinsufficient newborn mice. Am J Physiol Lung Cell Mol Physiol 308:L464-78
Milla, Carlos E; Moss, Richard B (2015) Recent advances in cystic fibrosis. Curr Opin Pediatr 27:317-24
Nickel, Nils P; Spiekerkoetter, Edda; Gu, Mingxia et al. (2015) Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling. Am J Respir Crit Care Med 191:1273-86
Jiang, Xinguo; Sung, Yon K; Tian, Wen et al. (2014) Graft microvascular disease in solid organ transplantation. J Mol Med (Berl) 92:797-810
Beraud, Anne-Sophie; Guillamet, Cristina Vazquez; Hammes, Jessie L et al. (2014) Efficacy of transthoracic echocardiography for diagnosing heart failure in septic shock. Am J Med Sci 347:295-8

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