Lung transplantation currently represents the only cure for a number of advanced lung diseases. Unfortunately, it is also the least successful solid organ transplant because of the very high incidence of BOS which affects >50% of lung transplant recipients in 5 years (18). Poor outcomes in lung transplantafion may be intimately related to the tenuous circulation supplying the airways (4, 5, 19). Given the link between loss of microvascular integrity and chronic rejection, the development of adjunctive vasculoprotective therapies, such as those described in this proposal, hold promise for significantly improving outcomes in lung transplantation.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL108797-04
Application #
8676923
Study Section
Special Emphasis Panel (ZHL1-PPG-A)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
4
Fiscal Year
2014
Total Cost
$320,813
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Jiang, Xinguo; Sung, Yon K; Tian, Wen et al. (2014) Graft microvascular disease in solid organ transplantation. J Mol Med (Berl) 92:797-810
Khan, Mohammad Afzal; Nicolls, Mark R; Surguladze, Besiki et al. (2014) Complement components as potential therapeutic targets for asthma treatment. Respir Med 108:543-9
Rabinovitch, Marlene; Guignabert, Christophe; Humbert, Marc et al. (2014) Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension. Circ Res 115:165-75
Beraud, Anne-Sophie; Guillamet, Cristina Vazquez; Hammes, Jessie L et al. (2014) Efficacy of transthoracic echocardiography for diagnosing heart failure in septic shock. Am J Med Sci 347:295-8
Jiang, Xinguo; Tian, Wen; Sung, Yon K et al. (2014) Macrophages in solid organ transplantation. Vasc Cell 6:5
Singh, Amar Bahadur; Li, Hai; Kan, Chin Fung Kelvin et al. (2014) The critical role of mRNA destabilizing protein heterogeneous nuclear ribonucleoprotein d in 3' untranslated region-mediated decay of low-density lipoprotein receptor mRNA in liver tissue. Arterioscler Thromb Vasc Biol 34:8-16
Tian, Wen; Jiang, Xinguo; Sung, Yon K et al. (2014) Leukotrienes in pulmonary arterial hypertension. Immunol Res 58:387-93
Sawada, Hirofumi; Saito, Toshie; Nickel, Nils P et al. (2014) Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension. J Exp Med 211:263-80
Jiang, Xinguo; Nicolls, Mark R (2014) Working toward immune tolerance in lung transplantation. J Clin Invest 124:967-70
Jiang, Xinguo; Malkovskiy, Andrey V; Tian, Wen et al. (2014) Promotion of airway anastomotic microvascular regeneration and alleviation of airway ischemia by deferoxamine nanoparticles. Biomaterials 35:803-13

Showing the most recent 10 out of 14 publications