Administrative Core: This core unit will be responsible for the overall administration and management of the Program Project. This core, which is responsible for four projects and four cores will be directed by Steven R. Houser, Ph.D., the Principal Investigator of the Program Project Grant. The Administrative core functions include: 1 .Overall scientific coordination of the research objectives of the Program Project Grant. This includes the review and recording of scientific progress made in all component projects and cores. 2. Follow and implement all guidelines for Program Project Grant, including administering the budget and subcontracts in accordance with all NIH, NHLBI and Temple University policies.3.Monitor ali expenditures for accuracy, fiscally responsibility for the projects and cores. 4. Facilitates and an-anges for interactions among the project leaders, direct collaboration with other institutions working in related areas. Arange, support and direct regular meetings of the Intemal and External Advisory Committee with the PPG investigators and core directors. S.Conduct and lead bi-weekly research data meetings that will be held for investigators, fellows, technicians and students involved in the projects and cores. Internet based meetings will be held so that all investigators at Cincinnati and at Jefferson can participate without having to travel to Temple. Core A will hold a bi-annual face to face meeting for all project core leaders and key personnel. 6.Support publication of new data resulting.from research projects. 7. Prepare annual reports and renewals for the Program Project Grant. This core will also be responsible for evaluation of progress of all portions of this PPG. This will be done in consultations with Intemal and Extemal advisory boards. The core will organize annual retreats so that students and fellows working on this project have an opportunity to present their work. This core will work with counterparts at collaborating Institutions to ensure progress is made at all sites.

Public Health Relevance

This Core will be responsible for all administrative and management decisions related to this PPG. The goal of the program is to identify novel approaches to treat patients with ischemic heart disease, or other cardiac maladies that cause premature death and disability.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
4P01HL108806-05
Application #
9020992
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2016-04-01
Budget End
2017-03-31
Support Year
5
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Temple University
Department
Type
DUNS #
057123192
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
de Lucia, Claudio; Gambino, Giuseppina; Petraglia, Laura et al. (2018) Long-Term Caloric Restriction Improves Cardiac Function, Remodeling, Adrenergic Responsiveness, and Sympathetic Innervation in a Model of Postischemic Heart Failure. Circ Heart Fail 11:e004153
Harper, Shavonn C; Johnson, Jaslyn; Borghetti, Giulia et al. (2018) GDF11 Decreases Pressure Overload-Induced Hypertrophy, but Can Cause Severe Cachexia and Premature Death. Circ Res 123:1220-1231
Cannavo, Alessandro; Koch, Walter J (2018) GRK2 as negative modulator of NO bioavailability: Implications for cardiovascular disease. Cell Signal 41:33-40
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Sharp 3rd, Thomas E; Kubo, Hajime; Berretta, Remus M et al. (2017) Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction. JACC Basic Transl Sci 2:669-683
Sharp 3rd, Thomas E; Schena, Giana J; Hobby, Alexander R et al. (2017) Cortical Bone Stem Cell Therapy Preserves Cardiac Structure and Function After Myocardial Infarction. Circ Res 121:1263-1278
Waldschmidt, Helen V; Homan, Kristoff T; Cato, Marilyn C et al. (2017) Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J Med Chem 60:3052-3069
Waldschmidt, Helen V; Homan, Kristoff T; Cruz-Rodríguez, Osvaldo et al. (2016) Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J Med Chem 59:3793-807
Harper, Shavonn C; Brack, Andrew; MacDonnell, Scott et al. (2016) Is Growth Differentiation Factor 11 a Realistic Therapeutic for Aging-Dependent Muscle Defects? Circ Res 118:1143-50; discussion 1150

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