The Administrative Core will provide centralized professional and administrative support to the Program and its Investigators. This includes overall monitoring of progress, organization of weekly meetings of research personnel, facilitation of communications among the units involved on the project, and coordination of the activities of the advisory committees.
The administrative core provides support to Project and Core directed toward studies of pulmonary surface liquid, seeking an understanding of how the lung confronts environmental stresses and how the lung fails in diseases of pulmonary surface liquid depletion or excess. This understanding should reveal novel therapeutic strategies to address major human lung diseases, including cystic fibrosis, COPD, and ARDS.
|Shobair, Mahmoud; Dagliyan, Onur; Kota, Pradeep et al. (2016) Gain-of-Function Mutation W493R in the Epithelial Sodium Channel Allosterically Reconfigures Intersubunit Coupling. J Biol Chem 291:3682-92|
|Yu, Dongfang; Davis, Richard M; Aita, Megumi et al. (2016) Characterization of Rat Meibomian Gland Ion and Fluid Transport. Invest Ophthalmol Vis Sci 57:2328-43|
|Dickey, Audrey S; Pineda, Victor V; Tsunemi, Taiji et al. (2016) PPAR-Î´ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically. Nat Med 22:37-45|
|Sesma, Juliana I; Weitzer, Clarissa D; Livraghi-Butrico, Alessandra et al. (2016) UDP-glucose promotes neutrophil recruitment in the lung. Purinergic Signal 12:627-635|
|Livraghi-Butrico, A; Grubb, B R; Wilkinson, K J et al. (2016) Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease. Mucosal Immunol :|
|Esther Jr, Charles R; Coakley, Raymond D; Henderson, Ashley G et al. (2015) Metabolomic Evaluation of Neutrophilic Airway Inflammation in Cystic Fibrosis. Chest 148:507-15|
|Lazarowski, Eduardo R; Harden, T Kendall (2015) UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation. Mol Pharmacol 88:151-60|
|Billet, Arnaud; Jia, Yanlin; Jensen, Tim et al. (2015) Regulation of the cystic fibrosis transmembrane conductance regulator anion channel by tyrosine phosphorylation. FASEB J 29:3945-53|
|Hildebrandt, Ellen; Ding, Haitao; Mulky, Alok et al. (2015) A stable human-cell system overexpressing cystic fibrosis transmembrane conductance regulator recombinant protein at the cell surface. Mol Biotechnol 57:391-405|
|Aleksandrov, Luba A; Jensen, Timothy J; Cui, Liying et al. (2015) Thermal stability of purified and reconstituted CFTR in a locked open channel conformation. Protein Expr Purif 116:159-66|
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