The major goal of this Program Project Grant (PPG) is to gain insight into the regulation of hypoxic adenosine responses in acute and chronic settings in order to advance novel adenosine-based therapies for the treatment of lung disease. The Project Leaders of this PPG have made substantial contributions to the understanding of adenosine signaling and the regulation of different injury processes, including acute and chronic lung disease. Furthermore, pharmaceutical companies are actively developing adenosine-based therapies to treat various disorders including lung disease. However, confusion over the beneficial and detrimental aspects of adenosine signaling has hindered these efforts. The experiments planned in the Component Projects of this PPG will address aspects of adenosine signaling in acute and chronic disease states with a focus on lung disease, and they will interact scientifically to understand organ and stage- specific aspects of adenosine signaling. It is hoped that the knowledge gained will help guide the development of specific adenosine-based therapies. However, we feel that this goal will be facilitated further by establishing mechanisms that promote interactions amongst the Project Research Teams, The Cores and Advisory Board Members. Thus, a major goal of this Administrative Core will be to provide administrative assistance to facilitate scheduled monthly meetings, Bi-Annual Project Leader Conferences, and a yearly PPG Scientific Retreat. These activities will focus on the exchange of data and ideas to understand the differences and similarities of the hypoxic adenosine response in different environments, and promote the importance of this pathway to the greater scientific community. Other goals of this Core include providing the administrative structure to assure the successful use of the Scientific Cores and the exchange of data and research material, monitor scientific progress of the Projects, address concerns, monitor compliance issues, and facilitate the presentation and publication of scientific results. By achieving these goals, this Administrative Core will contribute to the overall success and significance of this PPG.

Public Health Relevance

Acute and chronic lung diseases are the third leading cause of death behind cancer and cardiovascular disease. This is due in part to an incomplete understanding of injury responses in the lung. This Administrative Core is highly relevant to the betterment of human disease in that it will seek to facilitate interactions that are geared towards understanding novel mechanisms of lung disease that may lead to new treatments for these deadly lung disorders.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
Project #
Application #
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas Health Science Center Houston
United States
Zip Code
Idzko, Marco; Ferrari, Davide; Riegel, Ann-Kathrin et al. (2014) Extracellular nucleotide and nucleoside signaling in vascular and blood disease. Blood 124:1029-37
Le, Thanh-Thuy T; Karmouty-Quintana, Harry; Melicoff, Ernestina et al. (2014) Blockade of IL-6 Trans signaling attenuates pulmonary fibrosis. J Immunol 193:3755-68
Bartels, Karsten; Grenz, Almut; Eltzschig, Holger K (2014) Sphingosine-1-phosphate receptor signaling during acute kidney injury: the tissue is the issue. Kidney Int 85:733-5
Tak, Eunyoung; Ridyard, Douglas; Kim, Jae-Hwan et al. (2014) CD73-dependent generation of adenosine and endothelial Adora2b signaling attenuate diabetic nephropathy. J Am Soc Nephrol 25:547-63
Zhang, Yujin; Berka, Vladimir; Song, Anren et al. (2014) Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression. J Clin Invest 124:2750-61
Bartels, Karsten; Grenz, Almut; Eltzschig, Holger K (2014) Transforming high risk to high yield. Anesthesiology 120:1072-4
Eckle, Tobias; Kewley, Emily M; Brodsky, Kelley S et al. (2014) Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury. J Immunol 192:1249-56
Idzko, Marco; Ferrari, Davide; Eltzschig, Holger K (2014) Nucleotide signalling during inflammation. Nature 509:310-7
Eltzschig, Holger K; Bratton, Donna L; Colgan, Sean P (2014) Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases. Nat Rev Drug Discov 13:852-69
Ning, Chen; Wen, Jiaming; Zhang, Yujin et al. (2014) Excess adenosine A2B receptor signaling contributes to priapism through HIF-1? mediated reduction of PDE5 gene expression. FASEB J 28:2725-35

Showing the most recent 10 out of 13 publications