Core C represents the administrative core for the PPG program and focuses on three specific goals. Core C will provide fiscal and secretarial support for the general operations of the program. These services will be provided by dedicated business and secretarial personnel that are currently in place in the Airways Biology Initiative (ABI) in the Pulmonary, Allergy and Critical Care Division ofthe Department of Medicine. The ABI, directed by Dr. Panettieri, is a Center at the University of Pennsylvania and focuses on understanding mechanisms that promote the pathogenesis of airways diseases (asthma, COPD and cysticfibrosis).The second goal is to facilitate and coordinate scientific interactions and communication among the individual components ofthe PPG program. This will be accomplished through monthly meetings of a steering committee composed of project leaders/core directors, a monthly visiting professor and seminar program featuring invited scientists, and by "work-in-progress" presentations by the PPG participants. The third function ofthe administrative core will be to coordinate peer review of scientific progress. This will be accomplished through a semi-annual meeting ofthe internal advisory board, consisting of senior University of Pennsylvania-, Thomas Jefferson University- and University of Maryland-based investigators and a yearly meeting ofthe external advisory board, consisting of scientists from outside ofthe University of Pennsylvania who are experts in the areas related to the individual PPG projects. The PPG director will supervise the administrative core with the assistance from a business administrator and an administrative assistant. This critical core will ensure the efficient functioning of the project and will facilitate maximum scientific productivity ofthe program.

Public Health Relevance

Core C will provide fiscal and administrative infrastructure for the PPG. This core will facilitate communication among participants and ensure dissemination of scientific progress to the research and lay communities.

Agency
National Institute of Health (NIH)
Type
Research Program Projects (P01)
Project #
5P01HL114471-02
Application #
8701378
Study Section
Heart, Lung, and Blood Program Project Review Committee (HLBP)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Kim, Won-Keun; Jain, Deepika; Sánchez, Melissa D et al. (2014) Deficiency of melanoma differentiation-associated protein 5 results in exacerbated chronic postviral lung inflammation. Am J Respir Crit Care Med 189:437-48
Morgan, Sarah J; Deshpande, Deepak A; Tiegs, Brian C et al. (2014) ?-Agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent. J Biol Chem 289:23065-74
Damera, Gautam; Panettieri, Reynold A (2014) Irreversible airway obstruction in asthma: what we lose, we lose early. Allergy Asthma Proc 35:111-8
Pera, Tonio; Penn, Raymond B (2014) Crosstalk between beta-2-adrenoceptor and muscarinic acetylcholine receptors in the airway. Curr Opin Pharmacol 16:72-81
Kang, Dong Soo; Tian, Xufan; Benovic, Jeffrey L (2014) Role of ?-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking. Curr Opin Cell Biol 27:63-71
Liggett, Stephen B (2014) Bitter taste receptors in the wrong place: novel airway smooth muscle targets for treating asthma. Trans Am Clin Climatol Assoc 125:64-74; discussion 74-5
Hu, Ruoxi; Pan, Wenchi; Fedulov, Alexey V et al. (2014) MicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway. FASEB J 28:2347-57
Dileepan, Mythili; Jude, Joseph A; Rao, Savita P et al. (2014) MicroRNA-708 regulates CD38 expression through signaling pathways JNK MAP kinase and PTEN/AKT in human airway smooth muscle cells. Respir Res 15:107
Robinett, Kathryn S; Koziol-White, Cynthia J; Akoluk, Arda et al. (2014) Bitter taste receptor function in asthmatic and nonasthmatic human airway smooth muscle cells. Am J Respir Cell Mol Biol 50:678-83
Penn, Raymond B; Bond, Richard A; Walker, Julia K L (2014) GPCRs and arrestins in airways: implications for asthma. Handb Exp Pharmacol 219:387-403

Showing the most recent 10 out of 11 publications