The purpose of the Administrative and Biostatistics Core (Core A) is to coordinate the administrative and fiscal activities ofthe PPG and to provide Biostatistics support for all ofthe Projects. The Administrative Core will provide oversight and management of the budgetary aspects of the projects and cores of the PPG including compliance with institutional policy, implementing and interpreting grant policy for post award management and providing strategic directions for budgetary needs. The Core will facilitate ordering of supplies and equipment for the Projects and the Cores. The Administrative component will arrange meetings of PPG investigators and the advisory committees, organize the seminar series, and handle PPG related travel. In addition, the Administrative Core will handle communication with the NIH regarding budgetary issues, organize travel to scientific meetings, and coordinate the annual retreat. The Biostatistics portion of Core A will provide state-of-the art methods for experimental design and data analysis to all project investigators under the leadership of Dr. Shintani. The goals will be: to provide study design and review all laboratory, animal and clinical studies;to collaborate in data analysis, interpretation of results, and the writing of manuscripts;and to develop and evaluate statistical methods for experimental design and data analysis. Bioinformatics support for microRNA experiments will be provided by Drs. Guo and Ye (Core D). Although Core A is dedicated to Administration and Biostatistics, Dr. Ye and Dr. Guo are (Core D) are scientifically integrated and physically located with the biostatisticians of Core A within the VANGARD system. Vanderbilt Technologies for Advanced Genomics Analysis and Research Design (VANGARD) is a service core with administrative oversight from the Office of Research and scientific and technical direction provided by the Vanderbilt Center for Quantitative Sciences. Thus, data will be quickly analyzed and processed by skilled and experienced personnel in both bioinformatics and biostatistics.

Public Health Relevance

The purpose ofthe Administrative and Biostatistics Core (Core A) is to coordinate the administrative and fiscal activities ofthe PPG and to provide Biostatistics support for all ofthe Projects. The Administrative Core will provide oversight and management ofthe budgetary aspects ofthe projects and cores ofthe PPG. The Biostatistics portion of Core A will provide state-of-the art methods for experimental design and data analysis to all project investigators.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
1P01HL116263-01A1
Application #
8693114
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-04-30
Support Year
1
Fiscal Year
2014
Total Cost
$184,618
Indirect Cost
$66,902
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Ormseth, Michelle J; Stein, C Michael (2016) High-density lipoprotein function in rheumatoid arthritis. Curr Opin Lipidol 27:67-75
Ormseth, Michelle J; Yancey, Patricia G; Solus, Joseph F et al. (2016) Effect of Drug Therapy on Net Cholesterol Efflux Capacity of High-Density Lipoprotein-Enriched Serum in Rheumatoid Arthritis. Arthritis Rheumatol 68:2099-105
Babaev, Vladimir R; Yeung, Michele; Erbay, Ebru et al. (2016) Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice. Arterioscler Thromb Vasc Biol 36:1122-31
Michell, Danielle L; Vickers, Kasey C (2016) HDL and microRNA therapeutics in cardiovascular disease. Pharmacol Ther 168:43-52
Yang, Haichun; Fogo, Agnes B; Kon, Valentina (2016) Kidneys: key modulators of high-density lipoprotein levels and function. Curr Opin Nephrol Hypertens 25:174-9
Kon, Valentina; Linton, MacRae F (2016) HDL: Beyond Atheroprotection. J Am Soc Nephrol 27:341-4
Babaev, Vladimir R; Ding, Lei; Zhang, Youmin et al. (2016) Macrophage IKKα Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early Atherosclerosis. Arterioscler Thromb Vasc Biol 36:598-607
Beavers, Kelsey R; Werfel, Thomas A; Shen, Tianwei et al. (2016) Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids as Anti-MicroRNA Therapies. Adv Mater 28:7984-7992
Cheung, Kei-Hoi; Keerthikumar, Shivakumar; Roncaglia, Paola et al. (2016) Extending gene ontology in the context of extracellular RNA and vesicle communication. J Biomed Semantics 7:19
Michell, Danielle L; Vickers, Kasey C (2016) Lipoprotein carriers of microRNAs. Biochim Biophys Acta 1861:2069-2074

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