The Administrative Core will provide support for each of the five Projects as well as the Scientific Core.
The Aims of this Administrative Core are to ensure that the resources within the PPG are distributed equitably amongst the investigators, and that all the rules and regulations of the National Heart Lung and Blood Institute and the National Institute of Health are followed precisely. The Administrative Core will coordinate monthly meetings of the investigators and their laboratories, and will facilitate communication with both the Internal and External Advisory Boards. Ms. Michele Arlotta, Business Administrator of the Hematology/Oncology Division of the University of Pennsylvania School of Medicine, will organize the finances of the PPG. She will meet monthly with the PPG Principal Investigator, and quarterly with each Project and Core leader. Ms. Terese Manganaro will coordinate travel arrangements for the members of the PPG, as well as for the Advisors of the PPG who will visit Penn. For each PPG Investigator, she will also provide administrative support for their efforts related to the Program Project. It is anticipated that through the combined efforts of the Administrative Core Director (Dr. Abrams), Ms. Arlotta, and Ms. Manganaro, that the research performed by the individual Projects within the PPG will run more efficiently. Every effort was made to minimize the cost of this Administrative Core to maximize the funds available for the scientific goals of the Program.

Public Health Relevance

CORE A - NARRATIVE Platelet and coagulation factors play a role not only in the prevention of bleeding, but also in the development of heart attacks and strokes. This Program Project is focused on developing a better understanding of platelets and coagulation. The Administrative Core will support the researchers while they work to achieve this goal.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Heart, Lung, and Blood Initial Review Group (HLBP)
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University of Pennsylvania
United States
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Fong, Karen P; Zhu, Hua; Span, Lisa M et al. (2016) Directly Activating the Integrin αIIbβ3 Initiates Outside-In Signaling by Causing αIIbβ3 Clustering. J Biol Chem 291:11706-16
Lee, R H; Bergmeier, W (2016) Platelet immunoreceptor tyrosine-based activation motif (ITAM) and hemITAM signaling and vascular integrity in inflammation and development. J Thromb Haemost 14:645-54
Stefanini, Lucia; Bergmeier, Wolfgang (2016) RAP1-GTPase signaling and platelet function. J Mol Med (Berl) 94:13-9
Lozano, María Luisa; Cook, Aaron; Bastida, José María et al. (2016) Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction. Blood 128:1282-9
Zhou, Zinan; Tang, Alan T; Wong, Weng-Yew et al. (2016) Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. Nature 532:122-6
Welsh, John D; Muthard, Ryan W; Stalker, Timothy J et al. (2016) A systems approach to hemostasis: 4. How hemostatic thrombi limit the loss of plasma-borne molecules from the microvasculature. Blood 127:1598-605
Geddings, J E; Hisada, Y; Boulaftali, Y et al. (2016) Tissue factor-positive tumor microvesicles activate platelets and enhance thrombosis in mice. J Thromb Haemost 14:153-66
Piatt, Raymond; Paul, David S; Lee, Robert H et al. (2016) Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on Hemostasis. Arterioscler Thromb Vasc Biol 36:1838-46
Ivanciu, L; Stalker, T J (2015) Spatiotemporal regulation of coagulation and platelet activation during the hemostatic response in vivo. J Thromb Haemost 13:1949-59
Sayani, Farzana A; Abrams, Charles S (2015) How I treat refractory thrombotic thrombocytopenic purpura. Blood 125:3860-7

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