The Administrative Core will provide comprehensive administrative support for all Projects, as well as fulfill the reporting requirements to the NIH and provide ongoing tracking of the program's progress. The Core will be directed by Dr. Harris Gelbard, who has extensive administrative experience, and Dr. Dewhurst will serve as co-director of this Core and overall CoPI of the application. Specific functions of the core will include: (1) Provision of fiscal oversight for each project and overall to the PPG;(2) Coordination and oversight of intellectual property and technology commercialization issues in the PPG;(3) Coordination with the University of Rochester (UR)'s Clinical and Translational Sciences Institute (CTSI) and Developmental Center for AIDS Research (D-CFAR);(4) Provision of data/information exchange in a timely fashion to all investigators in the PPG;(5) Oversight of the PPG's Data Sharing plan and activities;(6) Coordination of communications among participating investigators and monitoring of program progress, (7) Support of the External Advisory Committee (EAC) and of scheduled program meetings;(8) Coordination of travel for scheduled meetings;(9) Provision of support for a planned application to the NIH RAID program, and for IND preparation and submission. Finally, Core A will also include Biostatistics and Biomathematic Image Modeling subcores, which will be led by Dr. Hulin Wu;Dr. Wu is also the Director of Biomathematics/Biostatistics/Bioinformatics (BBB) Core for the UR D-CFAR. The goal of the subcores will be (i) to develop and apply mathematical modeling and statistical methods to analyze neuroimaging data and also (ii) to provide biostatistical support for data analysis in all projects, consultative assistance with experimental design (power calculations).

Public Health Relevance

This program project proposal seeks to develop a new therapeutic intervention for HIV-associated neurocognitive disorders (HAND). To do this, it encompasses multiple institutions and a team of investigators with diverse expertise. The Administrative Core will serve as the glue to bind these investigators together, and will provide comprehensive administrative support for all projects.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Program Projects (P01)
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Special Emphasis Panel (ZMH1-ERB-M)
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University of Rochester
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Kevadiya, Bhavesh D; Ottemann, Brendan M; Thomas, Midhun Ben et al. (2018) Neurotheranostics as personalized medicines. Adv Drug Deliv Rev :
Zhou, Tian; Lin, Zhiyi; Puligujja, Pavan et al. (2018) Optimizing the preparation and stability of decorated antiretroviral drug nanocrystals. Nanomedicine (Lond) 13:871-885
McMillan, JoEllyn; Szlachetka, Adam; Zhou, Tian et al. (2018) Pharmacokinetic testing of a first generation cabotegravir prodrug in rhesus macaques. AIDS :
Hammond, Jennetta W; Qiu, Wen Q; Marker, Daniel F et al. (2018) HIV Tat causes synapse loss in a mouse model of HIV-associated neurocognitive disorder that is independent of the classical complement cascade component C1q. Glia 66:2563-2574
Olson, Katherine E; Bade, Aditya N; Namminga, Krista L et al. (2018) Persistent EcoHIV infection induces nigral degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice. J Neurovirol 24:398-410
Schutt, Charles R; Gendelman, Howard E; Mosley, R Lee (2018) Tolerogenic bone marrow-derived dendritic cells induce neuroprotective regulatory T cells in a model of Parkinson's disease. Mol Neurodegener 13:26
Sillman, Brady; Bade, Aditya N; Dash, Prasanta K et al. (2018) Creation of a long-acting nanoformulated dolutegravir. Nat Commun 9:443
Thomas, Midhun B; Gnanadhas, Divya Prakash; Dash, Prasanta K et al. (2018) Modulating cellular autophagy for controlled antiretroviral drug release. Nanomedicine (Lond) 13:2139-2154
Kiyota, Tomomi; Machhi, Jatin; Lu, Yaman et al. (2018) URMC-099 facilitates amyloid-? clearance in a murine model of Alzheimer's disease. J Neuroinflammation 15:137
Kevadiya, Bhavesh D; Woldstad, Christopher; Ottemann, Brendan M et al. (2018) Multimodal Theranostic Nanoformulations Permit Magnetic Resonance Bioimaging of Antiretroviral Drug Particle Tissue-Cell Biodistribution. Theranostics 8:256-276

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