The Administrative Core will provide comprehensive administrative support for all Projects, as well as fulfill the reporting requirements to the NIH and provide ongoing tracking of the program's progress. The Core will be directed by Dr. Harris Gelbard, who has extensive administrative experience, and Dr. Dewhurst will serve as co-director of this Core and overall CoPI of the application. Specific functions of the core will include: (1) Provision of fiscal oversight for each project and overall to the PPG;(2) Coordination and oversight of intellectual property and technology commercialization issues in the PPG;(3) Coordination with the University of Rochester (UR)'s Clinical and Translational Sciences Institute (CTSI) and Developmental Center for AIDS Research (D-CFAR);(4) Provision of data/information exchange in a timely fashion to all investigators in the PPG;(5) Oversight of the PPG's Data Sharing plan and activities;(6) Coordination of communications among participating investigators and monitoring of program progress, (7) Support of the External Advisory Committee (EAC) and of scheduled program meetings;(8) Coordination of travel for scheduled meetings;(9) Provision of support for a planned application to the NIH RAID program, and for IND preparation and submission. Finally, Core A will also include Biostatistics and Biomathematic Image Modeling subcores, which will be led by Dr. Hulin Wu;Dr. Wu is also the Director of Biomathematics/Biostatistics/Bioinformatics (BBB) Core for the UR D-CFAR. The goal of the subcores will be (i) to develop and apply mathematical modeling and statistical methods to analyze neuroimaging data and also (ii) to provide biostatistical support for data analysis in all projects, consultative assistance with experimental design (power calculations).

Public Health Relevance

This program project proposal seeks to develop a new therapeutic intervention for HIV-associated neurocognitive disorders (HAND). To do this, it encompasses multiple institutions and a team of investigators with diverse expertise. The Administrative Core will serve as the glue to bind these investigators together, and will provide comprehensive administrative support for all projects.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Program Projects (P01)
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Special Emphasis Panel (ZMH1-ERB-M)
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University of Rochester
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Kelso, Matthew L; Elliott, Bret R; Haverland, Nicole A et al. (2015) Granulocyte-macrophage colony stimulating factor exerts protective and immunomodulatory effects in cortical trauma. J Neuroimmunol 278:162-73
Gendelman, Howard E; Mosley, R Lee; Boska, Michael D et al. (2014) The promise of nanoneuromedicine. Nanomedicine (Lond) 9:171-6
Gendelman, Howard E; Gelbard, Harris A (2014) Adjunctive and long-acting nanoformulated antiretroviral therapies for HIV-associated neurocognitive disorders. Curr Opin HIV AIDS 9:585-90
Guo, Dongwei; Li, Tianyuzi; McMillan, JoEllyn et al. (2014) Small magnetite antiretroviral therapeutic nanoparticle probes for MRI of drug biodistribution. Nanomedicine (Lond) 9:1341-52
Singh, Dhirender; McMillan, JoEllyn M; Liu, Xin-Ming et al. (2014) Formulation design facilitates magnetic nanoparticle delivery to diseased cells and tissues. Nanomedicine (Lond) 9:469-85
Singh, Dhirender; McMillan, JoEllyn M; Kabanov, Alexander V et al. (2014) Bench-to-bedside translation of magnetic nanoparticles. Nanomedicine (Lond) 9:501-16
Edagwa, Benson J; Zhou, Tian; McMillan, JoEllyn M et al. (2014) Development of HIV reservoir targeted long acting nanoformulated antiretroviral therapies. Curr Med Chem 21:4186-98
Ivanisevic, Julijana; Epstein, Adrian A; Kurczy, Michael E et al. (2014) Brain region mapping using global metabolomics. Chem Biol 21:1575-84
Gendelman, Howard E; Balogh, Lajos P; Bawa, Raj et al. (2014) The 4th Annual Meeting of the American Society for Nanomedicine. J Neuroimmune Pharmacol 9 Suppl 1:S1-3
Polesskaya, Oksana; Wong, Christopher; Lebron, Luis et al. (2014) MLK3 regulates fMLP-stimulated neutrophil motility. Mol Immunol 58:214-22

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