Our goal of identifying novel antagonists of HlV-1 vif involves the efforts of four investigators at four different institutions. The research plan requires close communication between these groups, rapid exchange of data, research materials and reagents as well the ability to solicit input from the Scientific Advisory Board (SAB) and act on that input. These activities will be coordinated by the Administrative Core. The major functions of the Core will include: Coordinate biannual, in-person meetings between project leaders and the SAB in order to overview progress, set milestones and action items for the individual projects. Maintain budgetary oversight for the individual research components and, if necessary reallocate resources if recommended by the SAB. Promote continuous dialog between investigators engaged in the project through teleconferencing. Coordinate data sharing and the exchange of materials at different stages in the project. Coordinate preparation of progress reports to the NIH as well as an annual NIH site-visit. Coordinate the presentation of research findings at scientific meetings and publication of research findings.. Serve as an intermediary with the Commercial Ventures and Intellectual Property office ofthe participating Institutions as well as for any issues that arise through intellectual property agreements. Mario Stevenson, Ph.D. will serve as Director ofthe Administrative Core and will be assisted by Maria Pieiga who, as Administrator ofthe Division of Infectious Diseases, has extensive expertise in the oversight of NIH and Industry-funded projects.

Public Health Relevance

;Success of this program project proposal depends upon strong synergy and communication between the participating investigators. The Administrative Core will coordinate the activities ofthe investigators to ensure synergy and strong lines of communication between them.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Program Projects (P01)
Project #
1P01MH100942-01
Application #
8656187
Study Section
Special Emphasis Panel (ZMH1-ERB-M (01))
Project Start
Project End
Budget Start
2013-08-19
Budget End
2014-07-31
Support Year
1
Fiscal Year
2013
Total Cost
$113,293
Indirect Cost
$13,375
Name
University of Miami School of Medicine
Department
Type
DUNS #
052780918
City
Coral Gables
State
FL
Country
United States
Zip Code
33146
Stevenson, Mario (2017) HIV persistence in macrophages. Nat Med 23:538-539
Honeycutt, Jenna B; Thayer, William O; Baker, Caroline E et al. (2017) HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy. Nat Med 23:638-643
Mohammed, Idrees; Kummetha, Indrasena Reddy; Singh, Gatikrushna et al. (2016) 1,2,3-Triazoles as Amide Bioisosteres: Discovery of a New Class of Potent HIV-1 Vif Antagonists. J Med Chem 59:7677-82
Honeycutt, Jenna B; Wahl, Angela; Baker, Caroline et al. (2016) Macrophages sustain HIV replication in vivo independently of T cells. J Clin Invest 126:1353-66
Cunyat, Francesc; Rainho, Jennifer N; West, Brian et al. (2016) Colony-Stimulating Factor 1 Receptor Antagonists Sensitize Human Immunodeficiency Virus Type 1-Infected Macrophages to TRAIL-Mediated Killing. J Virol 90:6255-62
Sattentau, Quentin J; Stevenson, Mario (2016) Macrophages and HIV-1: An Unhealthy Constellation. Cell Host Microbe 19:304-10
Rainho, Jennifer N; Martins, Mauricio A; Cunyat, Francesc et al. (2015) Nef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8+ T Cell Killing. J Virol 89:10625-36
Stevenson, Mario (2015) Role of myeloid cells in HIV-1-host interplay. J Neurovirol 21:242-8
Patil, Veena S; Zhou, Rui; Rana, Tariq M (2014) Gene regulation by non-coding RNAs. Crit Rev Biochem Mol Biol 49:16-32
Yang, Chao-Shun; Rana, Tariq M (2013) Learning the molecular mechanisms of the reprogramming factors: let's start from microRNAs. Mol Biosyst 9:10-7

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