PROJECT 3 SEROTONIN AND SLEEP DISORDERED BREATHING IN PARKINSON DISEASE Sleep disturbance and excessive daytime somnolence are important non-motor/non-dopaminergic features of Parkinson disease (PD). Sleep disruption in PD is likely multifactorial but recent evidence suggests a high prevalence of sleep disordered breathing in PD, a surprising finding in view of the tendency for PD subjects to lose weight during their illness. PD is clearly a multisystem neurodegeneration with evidence indicating degeneration of central serotoninergic systems. Caudal brainstem serotoninergic neurons are key actors in controlling upper airway patency during sleep and degeneration of this group of neurons would be a plausible cause of sleep disordered breathing in PD. Our hypothesis is that loss of caudal brainstem serotoninergic neurons causes SDB in PD. We will evaluate this hypothesis by comparing the caudal brainstem [11C]DASB binding, a measure of serotoninergic neurons, in PD subjects with and without SDB. We predict greater loss of caudal brainstem [11C]DASB binding in PD subjects with SBD than in PD subjects without SDB. We predict an inverse correlation between indices of SDB and caudal brainstem [11C]DASB binding in PD subjects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS015655-30
Application #
8376380
Study Section
Special Emphasis Panel (ZNS1-SRB-E)
Project Start
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
30
Fiscal Year
2012
Total Cost
$91,212
Indirect Cost
$32,174
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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Snider, Jonathan; Müller, Martijn L T M; Kotagal, Vikas et al. (2015) Non-exercise physical activity attenuates motor symptoms in Parkinson disease independent from nigrostriatal degeneration. Parkinsonism Relat Disord 21:1227-31
do Couto-Filho, Carlos Eduardo Gomes; de Moraes, Paulo Hemerson; Alonso, Maria Beatriz Carrazzone et al. (2015) Accuracy in the Diagnosis of the Mental Nerve Loop. A Comparative Study Between Panoramic Radiography and Cone Beam Computed Tomography. International journal of morphology = Revista internacional de 33:327-332
Frey, Kirk A; Petrou, Myria (2015) Imaging Amyloidopathy in Parkinson Disease and Parkinsonian Dementia Syndromes. Clin Transl Imaging 3:57-64
Bohnen, Nicolaas I; Albin, Roger L; Müller, Martijn L T M et al. (2015) Frequency of cholinergic and caudate nucleus dopaminergic deficits across the predemented cognitive spectrum of Parkinson disease and evidence of interaction effects. JAMA Neurol 72:194-200

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