PROJECT 3 SEROTONIN AND SLEEP DISORDERED BREATHING IN PARKINSON DISEASE Sleep disturbance and excessive daytime somnolence are important non-motor/non-dopaminergic features of Parkinson disease (PD). Sleep disruption in PD is likely multifactorial but recent evidence suggests a high prevalence of sleep disordered breathing in PD, a surprising finding in view of the tendency for PD subjects to lose weight during their illness. PD is clearly a multisystem neurodegeneration with evidence indicating degeneration of central serotoninergic systems. Caudal brainstem serotoninergic neurons are key actors in controlling upper airway patency during sleep and degeneration of this group of neurons would be a plausible cause of sleep disordered breathing in PD. Our hypothesis is that loss of caudal brainstem serotoninergic neurons causes SDB in PD. We will evaluate this hypothesis by comparing the caudal brainstem [11C]DASB binding, a measure of serotoninergic neurons, in PD subjects with and without SDB. We predict greater loss of caudal brainstem [11C]DASB binding in PD subjects with SBD than in PD subjects without SDB. We predict an inverse correlation between indices of SDB and caudal brainstem [11C]DASB binding in PD subjects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS015655-30
Application #
8376380
Study Section
Special Emphasis Panel (ZNS1-SRB-E)
Project Start
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
30
Fiscal Year
2012
Total Cost
$91,212
Indirect Cost
$32,174
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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Chou, Kelvin L; Kotagal, Vikas; Bohnen, Nicolaas I (2016) Neuroimaging and clinical predictors of fatigue in Parkinson disease. Parkinsonism Relat Disord 23:45-9
Shah, Neha; Frey, Kirk A; Müller, Martijn L T M et al. (2016) Striatal and Cortical ?-Amyloidopathy and Cognition in Parkinson's Disease. Mov Disord 31:111-7
Haugen, Jacob; Müller, Martijn L T M; Kotagal, Vikas et al. (2016) Prevalence of impaired odor identification in Parkinson disease with imaging evidence of nigrostriatal denervation. J Neural Transm (Vienna) 123:421-4
do Couto-Filho, Carlos Eduardo Gomes; de Moraes, Paulo Hemerson; Alonso, Maria Beatriz Carrazzone et al. (2015) Accuracy in the Diagnosis of the Mental Nerve Loop. A Comparative Study Between Panoramic Radiography and Cone Beam Computed Tomography. Int J Morphol 33:327-332

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