PROJECT 3 SEROTONIN AND SLEEP DISORDERED BREATHING IN PARKINSON DISEASE Sleep disturbance and excessive daytime somnolence are important non-motor/non-dopaminergic features of Parkinson disease (PD). Sleep disruption in PD is likely multifactorial but recent evidence suggests a high prevalence of sleep disordered breathing in PD, a surprising finding in view of the tendency for PD subjects to lose weight during their illness. PD is clearly a multisystem neurodegeneration with evidence indicating degeneration of central serotoninergic systems. Caudal brainstem serotoninergic neurons are key actors in controlling upper airway patency during sleep and degeneration of this group of neurons would be a plausible cause of sleep disordered breathing in PD. Our hypothesis is that loss of caudal brainstem serotoninergic neurons causes SDB in PD. We will evaluate this hypothesis by comparing the caudal brainstem [11C]DASB binding, a measure of serotoninergic neurons, in PD subjects with and without SDB. We predict greater loss of caudal brainstem [11C]DASB binding in PD subjects with SBD than in PD subjects without SDB. We predict an inverse correlation between indices of SDB and caudal brainstem [11C]DASB binding in PD subjects.

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National Institute of Neurological Disorders and Stroke (NINDS)
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Shah, Neha; Frey, Kirk A; Müller, Martijn L T M et al. (2016) Striatal and Cortical β-Amyloidopathy and Cognition in Parkinson's Disease. Mov Disord 31:111-7
Haugen, Jacob; Müller, Martijn L T M; Kotagal, Vikas et al. (2016) Prevalence of impaired odor identification in Parkinson disease with imaging evidence of nigrostriatal denervation. J Neural Transm (Vienna) 123:421-4
Chou, Kelvin L; Kotagal, Vikas; Bohnen, Nicolaas I (2016) Neuroimaging and clinical predictors of fatigue in Parkinson disease. Parkinsonism Relat Disord 23:45-9
Kotagal, Vikas; Bohnen, Nicolaas I; Müller, Martijn L T M et al. (2015) Educational attainment and motor burden in Parkinson's disease. Mov Disord 30:1143-7
Müller, Martijn L T M; Bohnen, Nicolaas I; Kotagal, Vikas et al. (2015) Clinical markers for identifying cholinergic deficits in Parkinson's disease. Mov Disord 30:269-73
Albin, Roger L; Fisher-Hubbard, Amanda; Shanmugasundaram, Krithika et al. (2015) Post-Mortem evaluation of amyloid-dopamine terminal positron emission tomography dementia classifications. Ann Neurol 78:824-30
Snider, Jonathan; Müller, Martijn L T M; Kotagal, Vikas et al. (2015) Non-exercise physical activity attenuates motor symptoms in Parkinson disease independent from nigrostriatal degeneration. Parkinsonism Relat Disord 21:1227-31
do Couto-Filho, Carlos Eduardo Gomes; de Moraes, Paulo Hemerson; Alonso, Maria Beatriz Carrazzone et al. (2015) Accuracy in the Diagnosis of the Mental Nerve Loop. A Comparative Study Between Panoramic Radiography and Cone Beam Computed Tomography. International journal of morphology = Revista internacional de 33:327-332
Frey, Kirk A; Petrou, Myria (2015) Imaging Amyloidopathy in Parkinson Disease and Parkinsonian Dementia Syndromes. Clin Transl Imaging 3:57-64
Bohnen, Nicolaas I; Albin, Roger L; Müller, Martijn L T M et al. (2015) Frequency of cholinergic and caudate nucleus dopaminergic deficits across the predemented cognitive spectrum of Parkinson disease and evidence of interaction effects. JAMA Neurol 72:194-200

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