CORE B: TOMOGRAPHY AND DATA ANALYSIS The Tomography/Data Analysis Core provides the means necessary to perform the acquisition, workup, and analysis of all positron emission tomographic (PET) and magnetic resonance imaging (MRI) data generated from this program project grant. The Core has five principle functions: 1) a patient studies component to facilitate the acquisition and work-up of human PET studies;2) compartmental analysis and parameter estimation component to provide parametric measures for quantification of important biochemical and physiological parameters from dynamic PET/SPECT data;3) a data analysis component to facilitate the extraction of quantitative information from PET images for subsequent analysis, and to use magnetic resonance (MR) imaging for the purpose of combining anatomic and functional information including reorientation of data into a stereotactic reference system, the inverse mapping of stereotactically defined volumes-of-interest into the individual subject's frame of reference, as well as assessment of partial volume effects and tissue atrophy on the quantitative PET data;4) a data management component for efficient handling and storage of the large quantities of data that will be generated from the studies proposed in the grant application;and 5) a statistical analysis component that will be responsible for providing expertise in statistical matters for both experimental design and subsequent analysis of the data acquired in these projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS015655-30
Application #
8376385
Study Section
Special Emphasis Panel (ZNS1-SRB-E)
Project Start
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
30
Fiscal Year
2012
Total Cost
$302,064
Indirect Cost
$104,151
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Bohnen, Jeffrey L B; Müller, Martijn L T M; Haugen, Jacob et al. (2017) Mentally stimulating activities associate with better cognitive performance in Parkinson disease. J Neural Transm (Vienna) 124:1205-1212
Bohnen, Nicolaas I; Haugen, Jacob; Ridder, Andrew et al. (2017) Color discrimination errors associate with axial motor impairments in Parkinson's disease. Mov Disord Clin Pract 4:864-869
Kotagal, Vikas; Bohnen, Nicolaas I; Müller, Martijn L T M et al. (2017) Cerebral Amyloid Burden and Hoehn and Yahr Stage 3 Scoring in Parkinson Disease. J Parkinsons Dis 7:143-147
Ridder, A; Müller, M L T M; Kotagal, V et al. (2017) Impaired contrast sensitivity is associated with more severe cognitive impairment in Parkinson disease. Parkinsonism Relat Disord 34:15-19
Kim, Kamin; Müller, Martijn L T M; Bohnen, Nicolaas I et al. (2017) Thalamic cholinergic innervation makes a specific bottom-up contribution to signal detection: Evidence from Parkinson's disease patients with defined cholinergic losses. Neuroimage 149:295-304
Chou, Kelvin L; Gilman, Sid; Bohnen, Nicolaas I (2017) Association between autonomic dysfunction and fatigue in Parkinson disease. J Neurol Sci 377:190-192
Chou, Kelvin L; Kotagal, Vikas; Bohnen, Nicolaas I (2016) Neuroimaging and clinical predictors of fatigue in Parkinson disease. Parkinsonism Relat Disord 23:45-9
Shah, Neha; Frey, Kirk A; Müller, Martijn L T M et al. (2016) Striatal and Cortical ?-Amyloidopathy and Cognition in Parkinson's Disease. Mov Disord 31:111-7
Haugen, Jacob; Müller, Martijn L T M; Kotagal, Vikas et al. (2016) Prevalence of impaired odor identification in Parkinson disease with imaging evidence of nigrostriatal denervation. J Neural Transm (Vienna) 123:421-4
do Couto-Filho, Carlos Eduardo Gomes; de Moraes, Paulo Hemerson; Alonso, Maria Beatriz Carrazzone et al. (2015) Accuracy in the Diagnosis of the Mental Nerve Loop. A Comparative Study Between Panoramic Radiography and Cone Beam Computed Tomography. Int J Morphol 33:327-332

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