This program project application aims to continue studies on the molecular and biophysical mechanisms involved in neuronal signalling by the neurobiology group of the Biology Department at UCSD. Six separate projects, using a wide variety of animal models, from leeches and fruit flies to lobsters and frogs, will be undertaken. Ion channels, their regulation and modulation represent a major focus of the work since they represent identified membrane components of fundamental importance to neuronal signalling. Second messengers and intracellular cascade systems also represent a central unifying theme. Target selection during development and target mediated neuronal differentiation represent other foci of integrative signalling. The diversity of approaches provide an integrated analysis of signalling mechanisms from the molecular level to the functioning circuit.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS025916-08
Application #
2265726
Study Section
Special Emphasis Panel (SRC (01))
Project Start
1988-03-01
Project End
1997-02-28
Budget Start
1995-03-01
Budget End
1997-02-28
Support Year
8
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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