Abstract

Our projects cover a multidisciplinary, but coherent approach directed toward an understanding of unconventional viral dementias and their relationship to """"""""non infectious"""""""" dementias (e.g. Alzheimer's disease). Experimental CJD rodent models will be used to evaluate critical events during infection and progression of disease. Biochemical and genetic studies in parallel with morphological and infectivity studies are here proposed. We continue our search for true agent-specific (non-host) molecules (protein and nucleic acid). We also hope to define probes that will be of use in studies of Alzheimer's disease as well as in CJD. Such probes will facilitate comparisons of infectious dementias with those of unknown etiology, and will be used to analyze both experimental rodent material and precious human specimen of CJD, GSS and AD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS034569-15
Application #
2883684
Study Section
Special Emphasis Panel (ZRG7-SSS-2 (24))
Program Officer
Nunn, Michael
Project Start
1982-09-30
Project End
2003-11-30
Budget Start
1999-03-01
Budget End
2003-11-30
Support Year
15
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Surgery
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Gomez-Varela, David; Berg, Darwin K (2013) Lateral mobility of presynaptic ?7-containing nicotinic receptors and its relevance for glutamate release. J Neurosci 33:17062-71
Wang, Xulong; Lippi, Giordano; Carlson, David M et al. (2013) Activation of ?7-containing nicotinic receptors on astrocytes triggers AMPA receptor recruitment to glutamatergic synapses. J Neurochem 127:632-43
Lozada, Adrian F; Wang, Xulong; Gounko, Natalia V et al. (2012) Glutamatergic synapse formation is promoted by ?7-containing nicotinic acetylcholine receptors. J Neurosci 32:7651-61
Lozada, Adrian F; Wang, Xulong; Gounko, Natalia V et al. (2012) Induction of dendritic spines by ?2-containing nicotinic receptors. J Neurosci 32:8391-400
Gómez-Varela, David; Schmidt, Manuela; Schoellerman, Jeff et al. (2012) PMCA2 via PSD-95 controls calcium signaling by ?7-containing nicotinic acetylcholine receptors on aspiny interneurons. J Neurosci 32:6894-905
Arjona, Alvaro; Simarro, Laura; Islinger, Florian et al. (2004) Two Creutzfeldt-Jakob disease agents reproduce prion protein-independent identities in cell cultures. Proc Natl Acad Sci U S A 101:8768-73
Baker, Christopher A; Lu, Zhi Yun; Manuelidis, Laura (2004) Early induction of interferon-responsive mRNAs in Creutzfeldt-Jakob disease. J Neurovirol 10:29-40
Baker, Christopher A; Manuelidis, Laura (2003) Unique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease. Proc Natl Acad Sci U S A 100:675-9
Manuelidis, Laura; Lu, Zhi Yun (2003) Virus-like interference in the latency and prevention of Creutzfeldt-Jakob disease. Proc Natl Acad Sci U S A 100:5360-5
Manuelidis, Laura (2003) Transmissible encephalopathies: speculations and realities. Viral Immunol 16:123-39

Showing the most recent 10 out of 25 publications