Functional magnetic resonance imaging (fMRI) provides exquisitely detailed anatomic, physiological and functional images of the brain at high spatial and temporal resolution in co-registration, without ionizing radiation and at relatively low cost. The cohesive theme for this proposal is the comprehensive interdisciplinary approach to the development and application of fMRI at high spatial and temporal resolution to understanding higher cognitive function of the normal human brain. The technological infrastructure is in place, with the first human MR scanner custom-designed for fMRI at 3.0 Tesla with a control system for temporal integration of cognitive paradigms, behavioral responses, physiological changes and image acquisition. This interdisciplinary team of investigators combines expertise in imaging, engineering, psychology, cognitive science, neuroscience, statistics, computing and medicine to allow a cohesive approach to the application and development of fMRI to human cognitive function.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
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National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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Jacobs, Tom P
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University of Pittsburgh
Schools of Medicine
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Thulborn, Keith; Lui, Elaine; Guntin, Jonathan et al. (2016) Quantitative sodium MRI of the human brain at 9.4 T provides assessment of tissue sodium concentration and cell volume fraction during normal aging. NMR Biomed 29:137-43
Thulborn, Keith R (2008) MRI in the management of cerebrovascular disease to prevent stroke. Neurol Clin 26:897-921, vii-viii
Little, Deborah M; Thulborn, Keith R (2006) Prototype-distortion category learning: a two-phase learning process across a distributed network. Brain Cogn 60:233-43
Little, Deborah M; Shin, Silvia S; Sisco, Shannon M et al. (2006) Event-related fMRI of category learning: differences in classification and feedback networks. Brain Cogn 60:244-52
Kurata, Jiro; Thulborn, Keith R; Firestone, Leonard L (2005) The cross-modal interaction between pain-related and saccade-related cerebral activation: a preliminary study by event-related functional magnetic resonance imaging. Anesth Analg 101:449-56, table of contents
Koshino, Hideya; Carpenter, Patricia A; Keller, Timothy A et al. (2005) Interactions between the dorsal and the ventral pathways in mental rotation: an fMRI study. Cogn Affect Behav Neurosci 5:54-66
Thulborn, Keith R; Davis, Denise; Snyder, James et al. (2005) Sodium MR imaging of acute and subacute stroke for assessment of tissue viability. Neuroimaging Clin N Am 15:639-53, xi-xii
Little, Deborah M; Thulborn, Keith R (2005) Correlations of cortical activation and behavior during the application of newly learned categories. Brain Res Cogn Brain Res 25:33-47
Simo, Lucia S; Krisky, Christine M; Sweeney, John A (2005) Functional neuroanatomy of anticipatory behavior: dissociation between sensory-driven and memory-driven systems. Cereb Cortex 15:1982-91
Vaillancourt, David E; Mayka, Mary A; Thulborn, Keith R et al. (2004) Subthalamic nucleus and internal globus pallidus scale with the rate of change of force production in humans. Neuroimage 23:175-86

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