Integrative Study of Brain Vascular Malformations The Laboratory Core (Core C) will provide infrastructure and experimental methodology for the program. Core C will function as a small animal surgical lab, a cellular and molecular biology lab, an imaging analysis lab, and a transgenic animal breeding unit. Key portions of the in vivo experiments within the PPG will be performed in the Core, thus providing quality control and consistency for the experiments.
Our Specific Aims are:
(Aim 1) Provide several animal models to the laboratory projects, including reproducible vascular dysplasia models, a flow-induced adaptive outward arterial remodeling model, and human-to-mouse transplantation model in the mature rodent brain (Projects 2, 3 and 4);
(Aim 2) Continue to refine our current models and develop novel animal models using manipulation of growth factor stimulation, genetic background and hemodynamic manipulation;
(Aim 3) Facilitate transfer of human specimens and serve as the clinical tissue bank for human surgical specimens. Core C will assist in designing the experiments, writing experimental proposals, and solving methodological problems;it will also provide a forum for discussing and interpreting results.
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| Zhang, Rui; Zhu, Wan; Su, Hua (2016) Vascular Integrity in the Pathogenesis of Brain Arteriovenous Malformation. Acta Neurochir Suppl 121:29-35 |
| Potts, Matthew B; Lau, Darryl; Abla, Adib A et al. (2015) Current surgical results with low-grade brain arteriovenous malformations. J Neurosurg 122:912-20 |
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| Wang, Liang; Shi, Wanchao; Su, Zhiguo et al. (2015) Endovascular treatment of severe acute basilar artery occlusion. J Clin Neurosci 22:195-8 |
| Hashimoto, Mitsuo; Yanagisawa, Haruhiko; Minagawa, Shunsuke et al. (2015) TGF-?-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease. J Immunol 195:1182-90 |
| Brand, Oliver J; Somanath, Sangeeta; Moermans, Catherine et al. (2015) Transforming Growth Factor-? and Interleukin-1? Signaling Pathways Converge on the Chemokine CCL20 Promoter. J Biol Chem 290:14717-28 |
| Tada, Yoshiteru; Wada, Kosuke; Shimada, Kenji et al. (2014) Estrogen protects against intracranial aneurysm rupture in ovariectomized mice. Hypertension 63:1339-44 |
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