Phenotyping Core, The purpose of the Phenotyping Core is to identify and implement a set of efficient and expedient assessment tools that will elucidate common physiological and psychological abnormalities associated with a number of painful syndromes, which based on the diversity of bodily systems affected, have largely been considered in isolation. These complex persistent pain conditions (CPPCs) include episodic migraine (Subproject 1), vulvar vestibulitis (Subproject 2), fibromyalgia (Subproject 3), irritable bowel syndrome and temporo-mandibular disorders. To accomplish this goal, the Core has the following Specific Aims: 1. To develop and administer a package of advanced phenotyping procedures to four groups of pafient participants referred from the clinics associated with Subprojects 1-3 and the UNC Center for Functional Gl &Motility Disorders that will adequately and efficienfiy capture the important elements of physiological and psychological processes that are hypothesized to be involved in mechanisms that initiate and maintain the patients'pain condition. 2. To serve as the clinical administrative unit for the enrollment and management of patients with episodic migraine, vulvar vestibulitis, fibromyalgia, irritable bowel syndrome and the recruitment, screening, and enrollment of healthy non-CPPC control subjects for the psychophysical and psychosocial assessments that will used to study the four patients groups of Subprojects 1-3.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
Project #
Application #
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Chapel Hill
United States
Zip Code
Moss, Chailee F; Damitz, Lynn A; Gracely, Richard H et al. (2016) Dorsal clitoral nerve injury following transobturator midurethral sling. J Pain Res 9:727-730
Wu, Cindy; Damitz, Lynn; Karrat, Kimberly M et al. (2016) Clitoral Epidermal Inclusion Cyst Resection With Intraoperative Sensory Nerve Mapping Technique. Female Pelvic Med Reconstr Surg 22:e24-6
Ciszek, Brittney P; O'Buckley, Sandra C; Nackley, Andrea G (2016) Persistent Catechol-O-methyltransferase-dependent Pain Is Initiated by Peripheral ?-Adrenergic Receptors. Anesthesiology 124:1122-35
Oladosu, Folabomi A; Ciszek, Brittney P; O'Buckley, Sandra C et al. (2016) Novel intrathecal and subcutaneous catheter delivery systems in the mouse. J Neurosci Methods 264:119-28
Segall, Samantha K; Shabalina, Svetlana A; Meloto, Carolina B et al. (2015) Molecular genetic mechanisms of allelic specific regulation of murine Comt expression. Pain 156:1965-77
Applebaum, Elizabeth; Nackley, Andrea G; Bair, Eric et al. (2015) Genetic Variants in Cyclooxygenase-2 Contribute to Post-treatment Pain among Endodontic Patients. J Endod 41:1214-8
Meloto, Carolina B; Segall, Samantha K; Smith, Shad et al. (2015) COMT gene locus: new functional variants. Pain 156:2072-83
Convertino, Marino; Samoshkin, Alexander; Gauthier, Josee et al. (2015) ?-Opioid receptor 6-transmembrane isoform: A potential therapeutic target for new effective opioids. Prog Neuropsychopharmacol Biol Psychiatry 62:61-7
Ciszek, Brittney P; Khan, Asma A; Dang, Hong et al. (2015) MicroRNA expression profiles differentiate chronic pain condition subtypes. Transl Res 166:706-720.e11
Thieme, Kati; Turk, Dennis C; Gracely, Richard H et al. (2015) The relationship among psychological and psychophysiological characteristics of fibromyalgia patients. J Pain 16:186-96

Showing the most recent 10 out of 89 publications