Core A: Administrative Core - John D. Houle, Ph.D., Director This Core is charged with the logistics of managing the demands placed on each of the other proposed Core facilities, with maintaining a database of all animals used in the Program Projects and in providing quality control and Project management. This will be accomplished by weekly meetings of the entire Program faculty, staff, postdoctoral fellows, graduate students and technical assistants;by monthly meetings of the Project Pis and Core Directors and by interaction with the External Advisory Panel. Data management is greatiy facilitated by an established database which logs information on Project number, individuals involved, protocol number, animal history and analyses to be performed. This provides an ongoing record of the progress of individual projects and Core effort devoted to each project. This Core will oversee the distribution of funds for travel and for publication costs for each of the Projects As is customary with our group, all important decisions are made by the Pis after discussion, but in the case of disagreement the final determination of Core use will be made by the Program PI, Dr. Houle.

Public Health Relevance

It is the function of this Administration Core to oversee and manage the use of other Cores by the individual Projects animal models of spinal cord injury. Because all of the Projects will rely upon Core facilities and personnel to maintain uniformity of procedures among the Projects it is important to have centralized oversight of all Core activities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
2P01NS055976-06A1
Application #
8534984
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2013-04-15
Budget End
2014-03-31
Support Year
6
Fiscal Year
2013
Total Cost
$34,415
Indirect Cost
$12,140
Name
Drexel University
Department
Type
DUNS #
002604817
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Lee, Seung Joon; Kalinski, Ashley L; Twiss, Jeffery L (2014) Awakening the stalled axon - surprises in CSPG gradients. Exp Neurol 254:12-7
Jin, Ying; Bouyer, Julien; Haas, Christopher et al. (2014) Behavioral and anatomical consequences of repetitive mild thoracic spinal cord contusion injury in the rat. Exp Neurol 257:57-69
Singh, Anita; Krisa, Laura; Frederick, Kelly L et al. (2014) Forelimb locomotor rating scale for behavioral assessment of recovery after unilateral cervical spinal cord injury in rats. J Neurosci Methods 226:124-31
Graziano, Alessandro; Foffani, Guglielmo; Knudsen, Eric B et al. (2013) Passive exercise of the hind limbs after complete thoracic transection of the spinal cord promotes cortical reorganization. PLoS One 8:e54350
Houle, John D; Cote, Marie-Pascale (2013) Axon regeneration and exercise-dependent plasticity after spinal cord injury. Ann N Y Acad Sci 1279:154-63
Haas, Christopher; Fischer, Itzhak (2013) Human astrocytes derived from glial restricted progenitors support regeneration of the injured spinal cord. J Neurotrauma 30:1035-52
Liu, Gang; Detloff, Megan Ryan; Miller, Kassi N et al. (2012) Exercise modulates microRNAs that affect the PTEN/mTOR pathway in rats after spinal cord injury. Exp Neurol 233:447-56
Keeler, Benjamin E; Liu, Gang; Siegfried, Rachel N et al. (2012) Acute and prolonged hindlimb exercise elicits different gene expression in motoneurons than sensory neurons after spinal cord injury. Brain Res 1438:8-21
Ketschek, A R; Haas, C; Gallo, G et al. (2012) The roles of neuronal and glial precursors in overcoming chondroitin sulfate proteoglycan inhibition. Exp Neurol 235:627-37

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