CORE B: Behavior Core - Dr. Jed Shumsky and Ms. Kassi Miller, Co-Directors All projects are proposing that rehabiitative therapy is beneficial to regeneration, repair and recovery of function. Behavior is often noted as the final common output of the CNS. It requires the complex coordination of anatomical substrates, molecular and electrophysiological signals of intact anatomical substrates to elucidate seemingly simple behavior like taking a step or discriminating betiween a light touch or a noxious pinch. Therefore, the sensitivity, validity and reliability of rehabilitative and behavioral testing techniques are critical not only to the success of individual projects, but also for the success and interpretation of the Program Project as a whole. The goal of the Behavior Core is to provide a central facility to the Pis to provide rehabilitative training and/or assess the functional significance of rehabilitative or cellular grafting interventions proposed by the Pis. The Behavior Core provides assistance with experimental design, a centralized facility that is outfitted with at least 7 standardized paradigms for rehabilitative training and more than 25 standardized behavioral testing procotols to test motor, sensorimotor, sensory and autonomic function in rodents and cats after spinal cord injury. Finally, the Behavior Core provides individualized hands- on technical training for technical staff, graduate students, postdoctoral fellows, faculty and visiting faculty in behavioral testing or rehabilitative strategies.

Public Health Relevance

The purpose of this PPG is to utilize regenerative and rehabilitative strategies to promote improvements in functional behavioral recovery. It is imperative that standardized rehabilitative and behavioral testing techniques are employed for accurate interpretation of results. The Behavior Core will provide standardized behavioral equipment and training for personnel to ensure reliability and validity of results.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS055976-07
Application #
8652513
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
7
Fiscal Year
2014
Total Cost
$49,894
Indirect Cost
$17,600
Name
Drexel University
Department
Type
DUNS #
002604817
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Jin, Ying; Bouyer, Julien; Haas, Christopher et al. (2014) Behavioral and anatomical consequences of repetitive mild thoracic spinal cord contusion injury in the rat. Exp Neurol 257:57-69
Singh, Anita; Krisa, Laura; Frederick, Kelly L et al. (2014) Forelimb locomotor rating scale for behavioral assessment of recovery after unilateral cervical spinal cord injury in rats. J Neurosci Methods 226:124-31
Graziano, Alessandro; Foffani, Guglielmo; Knudsen, Eric B et al. (2013) Passive exercise of the hind limbs after complete thoracic transection of the spinal cord promotes cortical reorganization. PLoS One 8:e54350
Houle, John D; Cote, Marie-Pascale (2013) Axon regeneration and exercise-dependent plasticity after spinal cord injury. Ann N Y Acad Sci 1279:154-63
Haas, Christopher; Fischer, Itzhak (2013) Human astrocytes derived from glial restricted progenitors support regeneration of the injured spinal cord. J Neurotrauma 30:1035-52
Liu, Gang; Detloff, Megan Ryan; Miller, Kassi N et al. (2012) Exercise modulates microRNAs that affect the PTEN/mTOR pathway in rats after spinal cord injury. Exp Neurol 233:447-56
Keeler, Benjamin E; Liu, Gang; Siegfried, Rachel N et al. (2012) Acute and prolonged hindlimb exercise elicits different gene expression in motoneurons than sensory neurons after spinal cord injury. Brain Res 1438:8-21
Ketschek, A R; Haas, C; Gallo, G et al. (2012) The roles of neuronal and glial precursors in overcoming chondroitin sulfate proteoglycan inhibition. Exp Neurol 235:627-37

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