Project 4: """"""""Directional Diffusivity as a Window into the Pathology of MS""""""""1'3*7 As a direct translation of Project 1, Project 4 is a MRI centered study. It has become clear that the pathologies observed in MS patient CMS are varied. Conventional clinical MRI lacks specificity for these pathologies. The hypothesis to be tested is that the pathology of lesions in MS and related diseases can be identified in vivo within white matter tracts using directional diffusivities derived from DTI. The feasibility of using directional diffusivities obtained by DTI to discern pathology in the white matter tracts of brains and spinal cords of living humans will be determined. Project 4 will determine the ability of DTI to predict the evolution of acute gadolinium (Gd)-enhancing MS lesions into T1 hypointensities (""""""""black holes"""""""") over 1 year, determine whether A,|| and A,j_ can differentiate poor vs. good functional outcomes in MS patients with remote and stable cervical spinal cord (SC) lesions, prospectively examine patients with acute cervical transverse myelitis (TM) using DTI and to correlate the results with eventual recovery, and verify that axonal injury/loss is the substrate for changes in XH and that demyelination is the substrate for increased A.J. in human spinal cord using post-mortem CMS specimens (existing data).

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
Project #
Application #
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Saint Louis
United States
Zip Code
Cross, Anne H; Song, Sheng-Kwei (2017) ""A new imaging modality to non-invasively assess multiple sclerosis pathology"". J Neuroimmunol 304:81-85
Lin, Tsen-Hsuan; Chiang, Chia-Wen; Perez-Torres, Carlos J et al. (2017) Diffusion MRI quantifies early axonal loss in the presence of nerve swelling. J Neuroinflammation 14:78
Klein, Robyn S; Hunter, Christopher A (2017) Protective and Pathological Immunity during Central Nervous System Infections. Immunity 46:891-909
Adusumilli, Gautam; Trinkaus, Kathryn; Sun, Peng et al. (2017) Intensity ratio to improve black hole assessment in multiple sclerosis. Mult Scler Relat Disord 19:140-147
Hou, Jianghui; Baker, Lane A; Zhou, Lushan et al. (2016) Viral interactions with the blood-brain barrier: old dog, new tricks. Tissue Barriers 4:e1142492
Salimi, Hamid; Cain, Matthew D; Klein, Robyn S (2016) Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis. Neurotherapeutics 13:514-34
Kim, Joong Hee; Song, Sheng-Kwei; Haldar, Justin P (2016) Signal-to-noise ratio-enhancing joint reconstruction for improved diffusion imaging of mouse spinal cord white matter injury. Magn Reson Med 75:852-8
Yue, Xuyi; Jin, Hongjun; Liu, Hui et al. (2015) A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression. Org Biomol Chem 13:7928-39
Daniels, Brian P; Klein, Robyn S (2015) Knocking on Closed Doors: Host Interferons Dynamically Regulate Blood-Brain Barrier Function during Viral Infections of the Central Nervous System. PLoS Pathog 11:e1005096
Wang, Yong; Sun, Peng; Wang, Qing et al. (2015) Differentiation and quantification of inflammation, demyelination and axon injury or loss in multiple sclerosis. Brain 138:1223-38

Showing the most recent 10 out of 58 publications