The Administrative and Statistics Core will continue to provide administrative, statistical, and data sharing support for all Projects and Cores. The Program Project Grant (PPG) will be administered through the Neurology Dept at Washington Univ. Director Dr. Cross will be responsible for overall performance of the PPG. Day-to-day scientific and budgetary management of each Project or Core will be delegated to individual Principle Investigators (PIs). Investigators involved in the PPG will meet monthly for a "work in progress" scientific meeting. The Project PIs, Drs. Cross, Robyn Klein, Sheng-Kwei Song, and biostatistician Kathryn Trinkaus will constitute the Program Project Executive Committee, who will meet monthly to coordinate research activities and resource allocation. One or more outside speakers will be invited to address the group yearly. Dr. Trinkaus will direct Biostatistics within Core A and will work with Dr. Cross to review data from all Projects and Cores. Dr. Trinkaus will be available to provide guidance regarding experimental design and statistical analyses to all Project investigators. As a member of the Executive Committee Dr. Trinkaus will attend all group meetings, and will aid in maintenance of the PO1 database, begun during the first 5 years. She will help maintain our computerized system of data sharing within the PPG, in accordance with NINDS standards. Dr. Trinkaus is critical to the success of all six Projects and Cores, and thus will devote 3.0 cal mo (25% effort). The PPG Director will encourage the prompt publication of all research results. The Administrative Core will employ an administrative assistant (14% effort/1.73 cal mos) supervised by the PI. This will continue to be Nanette Bladdick. Dr. Cross will arrange regular input from the Internal Scientific Advisory Board. Progress of the PO1 will be shared with this Advisory Board at least yearly.

Public Health Relevance

Core A is responsible for coordinating the PPG research projects and other Core activities by providing administrative, biostatistical, and computer support for all PPG components. Core A is responsible for ensuring that scientific discoveries made in the PPG are disseminated via timely research publications and data sharing so that our research can be used to improve Public Health.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
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National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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Washington University
Saint Louis
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Lin, Tsen-Hsuan; Spees, William M; Chiang, Chia-Wen et al. (2014) Diffusion fMRI detects white-matter dysfunction in mice with acute optic neuritis. Neurobiol Dis 67:1-8
Lin, Tsen-Hsuan; Chiang, Chia-Wen; Trinkaus, Kathryn et al. (2014) Manganese-enhanced MRI (MEMRI) via topical loading of Mn(2+) significantly impairs mouse visual acuity: a comparison with intravitreal injection. NMR Biomed 27:390-8
Wang, Xiaojie; Cusick, Matthew F; Wang, Yong et al. (2014) Diffusion basis spectrum imaging detects and distinguishes coexisting subclinical inflammation, demyelination and axonal injury in experimental autoimmune encephalomyelitis mice. NMR Biomed 27:843-52
Chiang, Chia-Wen; Wang, Yong; Sun, Peng et al. (2014) Quantifying white matter tract diffusion parameters in the presence of increased extra-fiber cellularity and vasogenic edema. Neuroimage 101:310-9
Tu, Tsang-Wei; Budde, Matthew D; Xie, Mingqiang et al. (2014) Phase-aligned multiple spin-echo averaging: a simple way to improve signal-to-noise ratio of in vivo mouse spinal cord diffusion tensor image. Magn Reson Imaging 32:1335-43
Cruz-Orengo, Lillian; Daniels, Brian P; Dorsey, Denise et al. (2014) Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility. J Clin Invest 124:2571-84
Lin, Tsen-Hsuan; Kim, Joong Hee; Perez-Torres, Carlos et al. (2014) Axonal transport rate decreased at the onset of optic neuritis in EAE mice. Neuroimage 100:244-53
Durrant, Douglas M; Daniels, Brian P; Klein, Robyn S (2014) IL-1R1 signaling regulates CXCL12-mediated T cell localization and fate within the central nervous system during West Nile Virus encephalitis. J Immunol 193:4095-106
Williams, Jessica L; Patel, Jigisha R; Daniels, Brian P et al. (2014) Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system. J Exp Med 211:791-9
Spees, William M; Lin, Tsen-Hsuan; Song, Sheng-Kwei (2013) White-matter diffusion fMRI of mouse optic nerve. Neuroimage 65:209-15

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