The Administrative and Statistics Core will continue to provide administrative, statistical, and data sharing support for all Projects and Cores. The Program Project Grant (PPG) will be administered through the Neurology Dept at Washington Univ. Director Dr. Cross will be responsible for overall performance of the PPG. Day-to-day scientific and budgetary management of each Project or Core will be delegated to individual Principle Investigators (PIs). Investigators involved in the PPG will meet monthly for a "work in progress" scientific meeting. The Project PIs, Drs. Cross, Robyn Klein, Sheng-Kwei Song, and biostatistician Kathryn Trinkaus will constitute the Program Project Executive Committee, who will meet monthly to coordinate research activities and resource allocation. One or more outside speakers will be invited to address the group yearly. Dr. Trinkaus will direct Biostatistics within Core A and will work with Dr. Cross to review data from all Projects and Cores. Dr. Trinkaus will be available to provide guidance regarding experimental design and statistical analyses to all Project investigators. As a member of the Executive Committee Dr. Trinkaus will attend all group meetings, and will aid in maintenance of the PO1 database, begun during the first 5 years. She will help maintain our computerized system of data sharing within the PPG, in accordance with NINDS standards. Dr. Trinkaus is critical to the success of all six Projects and Cores, and thus will devote 3.0 cal mo (25% effort). The PPG Director will encourage the prompt publication of all research results. The Administrative Core will employ an administrative assistant (14% effort/1.73 cal mos) supervised by the PI. This will continue to be Nanette Bladdick. Dr. Cross will arrange regular input from the Internal Scientific Advisory Board. Progress of the PO1 will be shared with this Advisory Board at least yearly.

Public Health Relevance

Core A is responsible for coordinating the PPG research projects and other Core activities by providing administrative, biostatistical, and computer support for all PPG components. Core A is responsible for ensuring that scientific discoveries made in the PPG are disseminated via timely research publications and data sharing so that our research can be used to improve Public Health.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
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National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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Washington University
Saint Louis
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Cross, Anne H; Song, Sheng-Kwei (2016) "A new imaging modality to non-invasively assess multiple sclerosis pathology". J Neuroimmunol :
Kim, Joong Hee; Song, Sheng-Kwei; Haldar, Justin P (2016) Signal-to-noise ratio-enhancing joint reconstruction for improved diffusion imaging of mouse spinal cord white matter injury. Magn Reson Med 75:852-8
Salimi, Hamid; Cain, Matthew D; Klein, Robyn S (2016) Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis. Neurotherapeutics 13:514-34
Yue, Xuyi; Jin, Hongjun; Liu, Hui et al. (2015) A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression. Org Biomol Chem 13:7928-39
Cantoni, Claudia; Bollman, Bryan; Licastro, Danilo et al. (2015) TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta Neuropathol 129:429-47
Wang, Yong; Sun, Peng; Wang, Qing et al. (2015) Differentiation and quantification of inflammation, demyelination and axon injury or loss in multiple sclerosis. Brain 138:1223-38
Daniels, Brian P; Klein, Robyn S (2015) Knocking on Closed Doors: Host Interferons Dynamically Regulate Blood-Brain Barrier Function during Viral Infections of the Central Nervous System. PLoS Pathog 11:e1005096
Tu, Tsang-Wei; Budde, Matthew D; Xie, Mingqiang et al. (2014) Phase-aligned multiple spin-echo averaging: a simple way to improve signal-to-noise ratio of in vivo mouse spinal cord diffusion tensor image. Magn Reson Imaging 32:1335-43
Cruz-Orengo, Lillian; Daniels, Brian P; Dorsey, Denise et al. (2014) Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility. J Clin Invest 124:2571-84
Lin, Tsen-Hsuan; Chiang, Chia-Wen; Trinkaus, Kathryn et al. (2014) Manganese-enhanced MRI (MEMRI) via topical loading of Mn(2+) significantly impairs mouse visual acuity: a comparison with intravitreal injection. NMR Biomed 27:390-8

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