Objectives: The Image Data Acquisition, Analysis, and Modeling Core will be responsible for (1) supporting the MRI experimental design and execution for all projects;(2) developing an objective MRIimmunohistochemistry validation method;(3) improving data acquisition efficiency;(4) streamlining postprocessing procedures;and (5) participating in data interpretation and dissemination of all MRI results. Core C will explore the possibility of using T2 relaxometry, myelin water imaging, to detect and quantify multiple pathologies in CNS white matter. Core Services: Core C is specifically designed to support all Projects of this program project grant, not a general purposed service core unit to the community. Outside studies relevant to the scope of this PPG will be considered after the approval of Executive Committee (Drs. Cross, Klein, Song and Trinkaus). It is the responsibility of Core C to perform all necessary tasks assuring the success of all MRI measurements. Decision-Making: During the planning of this renewal of this PPG, members of the executive committee have met and discussed regularly on specific tasks of Core C. Thus, the Core Co-directors Song and Kim will work closely with all Project and Core personnel to perform the proposed MRI studies and modify if necessary as projects progress. Any conflict in experimental execution will first be resolved between the involved Project/Core directors and Song/Kim team. Any unresolved conflict will be resolved through the PPG Executive Committee. The data interpretation and dissemination will be conducted by all involved Project/Core personnel, submitting to Executive Committee for final approval.
The Core C will support the improvement of our special imaging methods, such that they can eventually be used to monitor patients for patient management, as endpoints in clinical trials of new therapies, and to better understand diseases of the central nervous system (brain, spinal cord and optic nerves).
|Lin, Tsen-Hsuan; Spees, William M; Chiang, Chia-Wen et al. (2014) Diffusion fMRI detects white-matter dysfunction in mice with acute optic neuritis. Neurobiol Dis 67:1-8|
|Lin, Tsen-Hsuan; Chiang, Chia-Wen; Trinkaus, Kathryn et al. (2014) Manganese-enhanced MRI (MEMRI) via topical loading of Mn(2+) significantly impairs mouse visual acuity: a comparison with intravitreal injection. NMR Biomed 27:390-8|
|Wang, Xiaojie; Cusick, Matthew F; Wang, Yong et al. (2014) Diffusion basis spectrum imaging detects and distinguishes coexisting subclinical inflammation, demyelination and axonal injury in experimental autoimmune encephalomyelitis mice. NMR Biomed 27:843-52|
|Chiang, Chia-Wen; Wang, Yong; Sun, Peng et al. (2014) Quantifying white matter tract diffusion parameters in the presence of increased extra-fiber cellularity and vasogenic edema. Neuroimage 101:310-9|
|Tu, Tsang-Wei; Budde, Matthew D; Xie, Mingqiang et al. (2014) Phase-aligned multiple spin-echo averaging: a simple way to improve signal-to-noise ratio of in vivo mouse spinal cord diffusion tensor image. Magn Reson Imaging 32:1335-43|
|Cruz-Orengo, Lillian; Daniels, Brian P; Dorsey, Denise et al. (2014) Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility. J Clin Invest 124:2571-84|
|Lin, Tsen-Hsuan; Kim, Joong Hee; Perez-Torres, Carlos et al. (2014) Axonal transport rate decreased at the onset of optic neuritis in EAE mice. Neuroimage 100:244-53|
|Durrant, Douglas M; Daniels, Brian P; Klein, Robyn S (2014) IL-1R1 signaling regulates CXCL12-mediated T cell localization and fate within the central nervous system during West Nile Virus encephalitis. J Immunol 193:4095-106|
|Williams, Jessica L; Patel, Jigisha R; Daniels, Brian P et al. (2014) Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system. J Exp Med 211:791-9|
|Spees, William M; Lin, Tsen-Hsuan; Song, Sheng-Kwei (2013) White-matter diffusion fMRI of mouse optic nerve. Neuroimage 65:209-15|
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