Objectives: The Image Data Acquisition, Analysis, and Modeling Core will be responsible for (1) supporting the MRI experimental design and execution for all projects; (2) developing an objective MRIimmunohistochemistry validation method; (3) improving data acquisition efficiency; (4) streamlining postprocessing procedures; and (5) participating in data interpretation and dissemination of all MRI results. Core C will explore the possibility of using T2 relaxometry, myelin water imaging, to detect and quantify multiple pathologies in CNS white matter. Core Services: Core C is specifically designed to support all Projects of this program project grant, not a general purposed service core unit to the community. Outside studies relevant to the scope of this PPG will be considered after the approval of Executive Committee (Drs. Cross, Klein, Song and Trinkaus). It is the responsibility of Core C to perform all necessary tasks assuring the success of all MRI measurements. Decision-Making: During the planning of this renewal of this PPG, members of the executive committee have met and discussed regularly on specific tasks of Core C. Thus, the Core Co-directors Song and Kim will work closely with all Project and Core personnel to perform the proposed MRI studies and modify if necessary as projects progress. Any conflict in experimental execution will first be resolved between the involved Project/Core directors and Song/Kim team. Any unresolved conflict will be resolved through the PPG Executive Committee. The data interpretation and dissemination will be conducted by all involved Project/Core personnel, submitting to Executive Committee for final approval.

Public Health Relevance

The Core C will support the improvement of our special imaging methods, such that they can eventually be used to monitor patients for patient management, as endpoints in clinical trials of new therapies, and to better understand diseases of the central nervous system (brain, spinal cord and optic nerves).

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
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National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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Washington University
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Cross, Anne H; Song, Sheng-Kwei (2017) ""A new imaging modality to non-invasively assess multiple sclerosis pathology"". J Neuroimmunol 304:81-85
Lin, Tsen-Hsuan; Chiang, Chia-Wen; Perez-Torres, Carlos J et al. (2017) Diffusion MRI quantifies early axonal loss in the presence of nerve swelling. J Neuroinflammation 14:78
Klein, Robyn S; Hunter, Christopher A (2017) Protective and Pathological Immunity during Central Nervous System Infections. Immunity 46:891-909
Adusumilli, Gautam; Trinkaus, Kathryn; Sun, Peng et al. (2017) Intensity ratio to improve black hole assessment in multiple sclerosis. Mult Scler Relat Disord 19:140-147
Hou, Jianghui; Baker, Lane A; Zhou, Lushan et al. (2016) Viral interactions with the blood-brain barrier: old dog, new tricks. Tissue Barriers 4:e1142492
Salimi, Hamid; Cain, Matthew D; Klein, Robyn S (2016) Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis. Neurotherapeutics 13:514-34
Kim, Joong Hee; Song, Sheng-Kwei; Haldar, Justin P (2016) Signal-to-noise ratio-enhancing joint reconstruction for improved diffusion imaging of mouse spinal cord white matter injury. Magn Reson Med 75:852-8
Yue, Xuyi; Jin, Hongjun; Liu, Hui et al. (2015) A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression. Org Biomol Chem 13:7928-39
Daniels, Brian P; Klein, Robyn S (2015) Knocking on Closed Doors: Host Interferons Dynamically Regulate Blood-Brain Barrier Function during Viral Infections of the Central Nervous System. PLoS Pathog 11:e1005096
Wang, Yong; Sun, Peng; Wang, Qing et al. (2015) Differentiation and quantification of inflammation, demyelination and axon injury or loss in multiple sclerosis. Brain 138:1223-38

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