Administrative Core of this P01 is composed of two components: 1) Scientific Program 2) Education. The Scientific Program component will be led by Flora M. Vaccarino, M.D., and will include Program, Internal Advisory and External Review Committees. The program Committee will meet regularly and is responsible for reviewing the research progress, ensure that the goals of the Program are met, assess significance of the data, and discuss future directions. Another major function of the Program Committee is to see that clinical and translational implications of the research are identified and separately pursued as appropriate. The Internal Advisory Committee is represented by a group of senior Yale investigators who will advise the Principal Investigator and the Project Directors on the quality of the ongoing research. In addition, it will help the Program Committee in the overall administration of the program by reviewing program progress at least once a year. The External Review Committee is a group of outside consultants that will periodically review the scientific findings of the Program and be available to discuss program issues with Dr. Vaccarino and members of the Program Committee. The educational component concerns the training of medical students, graduate students, postdoctoral associates, residents and clinical fellows in the Child Study Center and Departments of Pediatrics, Neurobiology, Pathology, Obstetrics and Gynecology, Comparative Medicine, Radiology and School of Epidemiology and Public Health. The Core supports monthly seminars of all investigators involved in the projects and Cores, Program Committee members, and occasionally invited internal speakers.

Public Health Relevance

Preterm birth is one of the major pediatric public health problems of our time. The goal of this P01 is to identify new means of therapeutic intervention to decrease the neurobehavioral sequelae of preterm birth. This will be approached under the auspices of four interrelated projects, all using our mouse model exposed to sublethal hypoxia between P3 and P11 .The Administrative Core will ensure that the scientific and educational goals of this Project are met.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
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National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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Yale University
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Zonouzi, Marzieh; Scafidi, Joseph; Li, Peijun et al. (2015) GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury. Nat Neurosci 18:674-82
Hall, Michael R; Yamamoto, Kota; Protack, Clinton D et al. (2015) Temporal regulation of venous extracellular matrix components during arteriovenous fistula maturation. J Vasc Access 16:93-106
Dimou, L; Gallo, V (2015) NG2-glia and their functions in the central nervous system. Glia 63:1429-51
Salmaso, Natalina; Dominguez, Moises; Kravitz, Jacob et al. (2015) Contribution of maternal oxygenic state to the effects of chronic postnatal hypoxia on mouse body and brain development. Neurosci Lett 604:12-7
Koch, Marco; Varela, Luis; Kim, Jae Geun et al. (2015) Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature 519:45-50
Dietrich, Marcelo O; Zimmer, Marcelo R; Bober, Jeremy et al. (2015) Hypothalamic Agrp neurons drive stereotypic behaviors beyond feeding. Cell 160:1222-32
Salmaso, Natalina; Jablonska, Beata; Scafidi, Joseph et al. (2014) Neurobiology of premature brain injury. Nat Neurosci 17:341-6
Salmaso, Natalina; Tomasi, Simone; Vaccarino, Flora M (2014) Neurogenesis and maturation in neonatal brain injury. Clin Perinatol 41:229-39
Gallo, Vittorio (2014) Lethal migration: the bradykinin story. J Physiol 592:4805-6
Scafidi, Joseph; Hammond, Timothy R; Scafidi, Susanna et al. (2014) Intranasal epidermal growth factor treatment rescues neonatal brain injury. Nature 506:230-4

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