Administrative Core of this P01 is composed of two components: 1) Scientific Program 2) Education. The Scientific Program component will be led by Flora M. Vaccarino, M.D., and will include Program, Internal Advisory and External Review Committees. The program Committee will meet regularly and is responsible for reviewing the research progress, ensure that the goals of the Program are met, assess significance of the data, and discuss future directions. Another major function of the Program Committee is to see that clinical and translational implications of the research are identified and separately pursued as appropriate. The Internal Advisory Committee is represented by a group of senior Yale investigators who will advise the Principal Investigator and the Project Directors on the quality of the ongoing research. In addition, it will help the Program Committee in the overall administration of the program by reviewing program progress at least once a year. The External Review Committee is a group of outside consultants that will periodically review the scientific findings of the Program and be available to discuss program issues with Dr. Vaccarino and members of the Program Committee. The educational component concerns the training of medical students, graduate students, postdoctoral associates, residents and clinical fellows in the Child Study Center and Departments of Pediatrics, Neurobiology, Pathology, Obstetrics and Gynecology, Comparative Medicine, Radiology and School of Epidemiology and Public Health. The Core supports monthly seminars of all investigators involved in the projects and Cores, Program Committee members, and occasionally invited internal speakers.

Public Health Relevance

Preterm birth is one of the major pediatric public health problems of our time. The goal of this P01 is to identify new means of therapeutic intervention to decrease the neurobehavioral sequelae of preterm birth. This will be approached under the auspices of four interrelated projects, all using our mouse model exposed to sublethal hypoxia between P3 and P11 .The Administrative Core will ensure that the scientific and educational goals of this Project are met.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS062686-05
Application #
8475682
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
5
Fiscal Year
2013
Total Cost
$66,054
Indirect Cost
$26,141
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Salmaso, Natalina; Jablonska, Beata; Scafidi, Joseph et al. (2014) Neurobiology of premature brain injury. Nat Neurosci 17:341-6
Kim, Jae Geun; Suyama, Shigetomo; Koch, Marco et al. (2014) Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nat Neurosci 17:908-10
Gallo, Vittorio; Deneen, Benjamin (2014) Glial development: the crossroads of regeneration and repair in the CNS. Neuron 83:283-308
Salmaso, Natalina; Tomasi, Simone; Vaccarino, Flora M (2014) Neurogenesis and maturation in neonatal brain injury. Clin Perinatol 41:229-39
Scafidi, Joseph; Hammond, Timothy R; Scafidi, Susanna et al. (2014) Intranasal epidermal growth factor treatment rescues neonatal brain injury. Nature 506:230-4
Gallo, Vittorio (2014) Lethal migration: the bradykinin story. J Physiol 592:4805-6
Agematsu, Kota; Korotcova, Ludmila; Scafidi, Joseph et al. (2014) Effects of preoperative hypoxia on white matter injury associated with cardiopulmonary bypass in a rodent hypoxic and brain slice model. Pediatr Res 75:618-25
Dietrich, Marcelo O; Liu, Zhong-Wu; Horvath, Tamas L (2013) Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity. Cell 155:188-99
Murata, Akira; Agematsu, Kota; Korotcova, Ludmila et al. (2013) Rodent brain slice model for the study of white matter injury. J Thorac Cardiovasc Surg 146:1526-1533.e1
Schneeberger, Marc; Dietrich, Marcelo O; Sebastian, David et al. (2013) Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell 155:172-87

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