- CORE A The administrative core will serve to facilitate communication between the three projects and the cores. This will be accomplished by arranging live video conferences on a regular basis to facilitate data sharing and analysis. The administrative core will schedule these conferences. Large data files are shared between all the project and core leaders and these are managed by the administrative core. The administrative core will track and analyze expenditures submitted to Brown from the PIs of projects #1 and #3 and from core B. Ms Patricia Werner has experience in these activities as she currently manages a multi-component COBRE account for Dr. Atwood. Invoices will be reviewed monthly by Dr. Atwood and by Ms Werner and when approved will be sent to accounts payable for immediate payment. The administrative core will assist in the preparation of annual progress reports. This will be done yearly well in advance of the deadlines for submitting progress reports. Ms. Werner will be responsible for collating these reports electronically and forwarding them to the appropriate awarding institute.

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National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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Maginnis, Melissa S; Nelson, Christian D S; Atwood, Walter J (2015) JC polyomavirus attachment, entry, and trafficking: unlocking the keys to a fatal infection. J Neurovirol 21:601-13
Zins, Stephen R; Nelson, Christian D S; Maginnis, Melissa S et al. (2014) The human alpha defensin HD5 neutralizes JC polyomavirus infection by reducing endoplasmic reticulum traffic and stabilizing the viral capsid. J Virol 88:948-60
O'Hara, Bethany A; Rupasinghe, Chamila; Yatawara, Achani et al. (2014) Gallic acid-based small-molecule inhibitors of JC and BK polyomaviral infection. Virus Res 189:280-5
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Neu, Ursula; Allen, Stacy-Ann A; Blaum, Barbel S et al. (2013) A structure-guided mutation in the major capsid protein retargets BK polyomavirus. PLoS Pathog 9:e1003688
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Gee, Gretchen V; O'Hara, Bethany A; Derdowski, Aaron et al. (2013) Pseudovirus mimics cell entry and trafficking of the human polyomavirus JCPyV. Virus Res 178:281-6
Maginnis, Melissa S; Stroh, Luisa J; Gee, Gretchen V et al. (2013) Progressive multifocal leukoencephalopathy-associated mutations in the JC polyomavirus capsid disrupt lactoseries tetrasaccharide c binding. MBio 4:e00247-13
Lipovsky, Alex; Popa, Andreea; Pimienta, Genaro et al. (2013) Genome-wide siRNA screen identifies the retromer as a cellular entry factor for human papillomavirus. Proc Natl Acad Sci U S A 110:7452-7
Yatawara, Achani K; Hodoscek, Milan; Mierke, Dale F (2013) Ligand binding site identification by higher dimension molecular dynamics. J Chem Inf Model 53:674-80

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