Abstract

- CORE A The administrative core will serve to facilitate communication between the three projects and the cores. This will be accomplished by arranging live video conferences on a regular basis to facilitate data sharing and analysis. The administrative core will schedule these conferences. Large data files are shared between all the project and core leaders and these are managed by the administrative core. The administrative core will track and analyze expenditures submitted to Brown from the PIs of projects #1 and #3 and from core B. Ms Patricia Werner has experience in these activities as she currently manages a multi-component COBRE account for Dr. Atwood. Invoices will be reviewed monthly by Dr. Atwood and by Ms Werner and when approved will be sent to accounts payable for immediate payment. The administrative core will assist in the preparation of annual progress reports. This will be done yearly well in advance of the deadlines for submitting progress reports. Ms. Werner will be responsible for collating these reports electronically and forwarding them to the appropriate awarding institute.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
2P01NS065719-06
Application #
8789635
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-05-31
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost

  Institution

Name
Brown University
Department
Type
DUNS #
City
Providence
State
RI
Country
United States
Zip Code
02912

  Publications

O'Hara, Bethany A; Gee, Gretchen V; Atwood, Walter J et al. (2018) Susceptibility of Primary Human Choroid Plexus Epithelial Cells and Meningeal Cells to Infection by JC Virus. J Virol 92:
Haley, Sheila A; Atwood, Walter J (2017) Progressive Multifocal Leukoencephalopathy: Endemic Viruses and Lethal Brain Disease. Annu Rev Virol 4:349-367
Assetta, Benedetta; Atwood, Walter J (2017) The biology of JC polyomavirus. Biol Chem 398:839-855
Dietrich, Melanie H; Harprecht, Christina; Stehle, Thilo (2017) The bulky and the sweet: How neutralizing antibodies and glycan receptors compete for virus binding. Protein Sci 26:2342-2354
Dimitriadi, Maria; Derdowski, Aaron; Kalloo, Geetika et al. (2016) Decreased function of survival motor neuron protein impairs endocytic pathways. Proc Natl Acad Sci U S A 113:E4377-86
Assetta, Benedetta; De Cecco, Marco; O'Hara, Bethany et al. (2016) JC Polyomavirus Infection of Primary Human Renal Epithelial Cells Is Controlled by a Type I IFN-Induced Response. MBio 7:
Luo, Yong; Motamedi, Nasim; Magaldi, Thomas G et al. (2016) Interaction between Simian Virus 40 Major Capsid Protein VP1 and Cell Surface Ganglioside GM1 Triggers Vacuole Formation. MBio 7:e00297
Ströh, Luisa J; Maginnis, Melissa S; Blaum, Bärbel S et al. (2015) The Greater Affinity of JC Polyomavirus Capsid for ?2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of Infectivity. J Virol 89:6364-75
Nelson, Christian D S; Ströh, Luisa J; Gee, Gretchen V et al. (2015) Modulation of a pore in the capsid of JC polyomavirus reduces infectivity and prevents exposure of the minor capsid proteins. J Virol 89:3910-21
Maginnis, Melissa S; Nelson, Christian D S; Atwood, Walter J (2015) JC polyomavirus attachment, entry, and trafficking: unlocking the keys to a fatal infection. J Neurovirol 21:601-13

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